Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population
Recent studies suggest that hyperuricemia is a potential risk factor for cardiovascular disease (CVD). Hyperuricemia is highly heritable and is associated with sex and body weight. Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664615004064 |
| _version_ | 1819155372628246528 |
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| author | Shih-Tsung Cheng Semon Wu Cheng-Wen Su Ming-Sheng Teng Lung-An Hsu Yu-Lin Ko |
| author_facet | Shih-Tsung Cheng Semon Wu Cheng-Wen Su Ming-Sheng Teng Lung-An Hsu Yu-Lin Ko |
| author_sort | Shih-Tsung Cheng |
| collection | DOAJ |
| description | Recent studies suggest that hyperuricemia is a potential risk factor for cardiovascular disease (CVD). Hyperuricemia is highly heritable and is associated with sex and body weight. Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) levels, and the degree of association between rs2231142 and hyperuricemia is affected by both sex and ethnicity. This investigation aimed to analyze the association between ABCG2 polymorphisms and UA levels, as well as their interactions with sex and obesity in Taiwanese.
Methods: Two genetic polymorphisms around the ABCG2 gene were genotyped in 459 patients.
Results: After adjusting for clinical covariates, the rs2231142 SNP was found significantly associated with UA levels using a dominant inheritance model. Patients carrying the rs2231142-A allele had a higher frequency of hyperuricemia than those with the rs2231142-CC allele. Subgroup analysis revealed an association of rs2231142 with UA levels in male or obese patients, and there was no association in nonobese female patients.
Conclusion: The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients. Hyperuricemia might be controlled differently by sex and obesity. |
| first_indexed | 2024-12-22T15:35:56Z |
| format | Article |
| id | doaj.art-73d30df98f944a68916b1350aac14109 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-22T15:35:56Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-73d30df98f944a68916b1350aac141092022-12-21T18:21:15ZengElsevierJournal of the Formosan Medical Association0929-66462017-01-011161182310.1016/j.jfma.2015.12.002Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese populationShih-Tsung Cheng0Semon Wu1Cheng-Wen Su2Ming-Sheng Teng3Lung-An Hsu4Yu-Lin Ko5The Division of Cardiology, Department of Internal Medicine and Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, TaiwanThe Division of Cardiology, Department of Internal Medicine and Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, TaiwanThe First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, TaiwanThe Division of Cardiology, Department of Internal Medicine and Cardiovascular Medical Center, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, TaiwanRecent studies suggest that hyperuricemia is a potential risk factor for cardiovascular disease (CVD). Hyperuricemia is highly heritable and is associated with sex and body weight. Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) levels, and the degree of association between rs2231142 and hyperuricemia is affected by both sex and ethnicity. This investigation aimed to analyze the association between ABCG2 polymorphisms and UA levels, as well as their interactions with sex and obesity in Taiwanese. Methods: Two genetic polymorphisms around the ABCG2 gene were genotyped in 459 patients. Results: After adjusting for clinical covariates, the rs2231142 SNP was found significantly associated with UA levels using a dominant inheritance model. Patients carrying the rs2231142-A allele had a higher frequency of hyperuricemia than those with the rs2231142-CC allele. Subgroup analysis revealed an association of rs2231142 with UA levels in male or obese patients, and there was no association in nonobese female patients. Conclusion: The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients. Hyperuricemia might be controlled differently by sex and obesity.http://www.sciencedirect.com/science/article/pii/S0929664615004064obesitypolymorphismsexsingle nucleotideuric acid |
| spellingShingle | Shih-Tsung Cheng Semon Wu Cheng-Wen Su Ming-Sheng Teng Lung-An Hsu Yu-Lin Ko Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population Journal of the Formosan Medical Association obesity polymorphism sex single nucleotide uric acid |
| title | Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population |
| title_full | Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population |
| title_fullStr | Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population |
| title_full_unstemmed | Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population |
| title_short | Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population |
| title_sort | association of abcg2 rs2231142 a allele and serum uric acid levels in male and obese individuals in a han taiwanese population |
| topic | obesity polymorphism sex single nucleotide uric acid |
| url | http://www.sciencedirect.com/science/article/pii/S0929664615004064 |
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