Targeting sarcoma tumor-initiating cells through differentiation therapy

Targeting sarcoma tumor-initiating cells through differentiation therapy

Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells tha...

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Bibliographic Details
Main Authors: Dan Han, Veronica Rodriguez-Bravo, Elizabeth Charytonowicz, Elizabeth Demicco, Josep Domingo-Domenech, Robert G. Maki, Carlos Cordon-Cardo
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Stem Cell Research
Subjects:
Human leukocyte antigen class I
Tumor-initiating cells
Sarcomas
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300703

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