Hydroxychloroquine (HCQ) Modulates Autophagy and Oxidative DNA Damage Stress in Hepatocellular Carcinoma to Overcome Sorafenib Resistance via TLR9/SOD1/hsa-miR-30a-5p/Beclin-1 Axis

Hydroxychloroquine (HCQ) Modulates Autophagy and Oxidative DNA Damage Stress in Hepatocellular Carcinoma to Overcome Sorafenib Resistance via TLR9/SOD1/hsa-miR-30a-5p/Beclin-1 Axis

Sorafenib is used for treating advanced hepatocellular carcinoma (HCC), but some patients acquire sorafenib resistance. We investigated the mechanisms underlying acquired sorafenib resistance in HCC cells and targeted them to re-sensitize them to sorafenib. In silico analysis indicated that toll-lik...

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Bibliographic Details
Main Authors: Ming-Yao Chen, Vijesh Kumar Yadav, Yi Cheng Chu, Jiann Ruey Ong, Ting-Yi Huang, Kwai-Fong Lee, Kuen-Haur Lee, Chi-Tai Yeh, Wei-Hwa Lee
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
hepatocellular carcinoma
TLR9
HCQ
autophagy
oxidative stress
sorafenib resistance
Online Access:https://www.mdpi.com/2072-6694/13/13/3227

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