Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology
Combinatorial biology methods such as phage and yeast display, suitable for the generation and screening of huge numbers of protein fragments and mutated variants, have been useful when dissecting the molecular details of the interactions between antibodies and their target antigens (mainly those of...
Main Author: | Gertrudis Rojas |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-07-01
|
Series: | Antibodies |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4468/11/3/48 |
Similar Items
-
Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies
by: Chang Liu, et al.
Published: (2022-11-01) -
The Structural Basis of Antibody-Antigen Recognition
by: Inbal eSela-Culang, et al.
Published: (2013-10-01) -
Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns
by: Orla Cunningham, et al.
Published: (2021-01-01) -
Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
by: Jan Fredrik Simons, et al.
Published: (2020-01-01) -
A comparison of the binding sites of antibodies and single-domain antibodies
by: Gemma L. Gordon, et al.
Published: (2023-07-01)