Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins
White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy m...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34964-5 |
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author | Ravikanth Nanduri Takashi Furusawa Alexei Lobanov Bing He Carol Xie Kimia Dadkhah Michael C. Kelly Oksana Gavrilova Frank J. Gonzalez Michael Bustin |
author_facet | Ravikanth Nanduri Takashi Furusawa Alexei Lobanov Bing He Carol Xie Kimia Dadkhah Michael C. Kelly Oksana Gavrilova Frank J. Gonzalez Michael Bustin |
author_sort | Ravikanth Nanduri |
collection | DOAJ |
description | White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice. |
first_indexed | 2024-04-13T08:06:59Z |
format | Article |
id | doaj.art-73d8ac3438a74fbb8ecb66a525062117 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-13T08:06:59Z |
publishDate | 2022-11-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-73d8ac3438a74fbb8ecb66a5250621172022-12-22T02:55:07ZengNature PortfolioNature Communications2041-17232022-11-0113111510.1038/s41467-022-34964-5Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteinsRavikanth Nanduri0Takashi Furusawa1Alexei Lobanov2Bing He3Carol Xie4Kimia Dadkhah5Michael C. Kelly6Oksana Gavrilova7Frank J. Gonzalez8Michael Bustin9Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthCCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthNucleic Acid Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthCCR Single Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer ResearchCCR Single Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer ResearchMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthNucleic Acid Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthProtein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthWhite adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice.https://doi.org/10.1038/s41467-022-34964-5 |
spellingShingle | Ravikanth Nanduri Takashi Furusawa Alexei Lobanov Bing He Carol Xie Kimia Dadkhah Michael C. Kelly Oksana Gavrilova Frank J. Gonzalez Michael Bustin Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins Nature Communications |
title | Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins |
title_full | Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins |
title_fullStr | Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins |
title_full_unstemmed | Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins |
title_short | Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins |
title_sort | epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding hmgn proteins |
url | https://doi.org/10.1038/s41467-022-34964-5 |
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