The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India
Background: Coagulase-negative Staphylococcus (CoNS) are known commensals and often contaminate neonatal blood cultures. Their unique ability to form biofilms, however, helps them evade immune mechanisms and antibiotics and cause neonatal sepsis (NS) in hospitalized neonates. True or probable Coagul...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-11-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/56380 |
| _version_ | 1797640338015256576 |
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| author | Mausumi Mukherjee Sumon Poddar Barnali Das Amrita Mukherjee Shubhojit Deysarkar Madhura Mukherjee |
| author_facet | Mausumi Mukherjee Sumon Poddar Barnali Das Amrita Mukherjee Shubhojit Deysarkar Madhura Mukherjee |
| author_sort | Mausumi Mukherjee |
| collection | DOAJ |
| description | Background: Coagulase-negative Staphylococcus (CoNS) are known commensals and often contaminate neonatal blood cultures. Their unique ability to form biofilms, however, helps them evade immune mechanisms and antibiotics and cause neonatal sepsis (NS) in hospitalized neonates. True or probable Coagulase-negative Staphylococcus blood stream infection (CoNS BSI) must be differentiated from contaminants so that antibiotics are used judiciously and hospital stay is minimized.
Aims and Objectives: The primary objective of the study was to estimate the proportion of NS and contaminants among CoNS-positive blood cultures in the index neonatal unit and the host and health-care variables associated with CoNS BSI. The secondary objective was to estimate the susceptibility of CoNS isolates to antibiotics used.
Materials and Methods: This was a retrospective study from digital records, from January 2018 to December 2022.
Results: 25% of CoNS isolates were associated with NS (health-care infections) and 75% were contaminants. Over 90% of CoNS BSI was associated with central lines (CLs) and prolonged hospital stay. All isolates were resistant to oxacillin while resistance to gentamicin rose annually to over 68%. Susceptibility to linezolid and vancomycin was present, but a few strains were resistant to them.
Conclusion: CoNS were an important cause of NS in the index hospital. Prolonged hospital stays and CLs were associated with increased incidence of CoNS sepsis and must be minimized where possible. Antibiotic resistance was high, and reserve drugs could also become ineffective. |
| first_indexed | 2024-03-11T13:30:31Z |
| format | Article |
| id | doaj.art-73dac45048e74bc88d4fbeabcf7c5c12 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-11T13:30:31Z |
| publishDate | 2023-11-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-73dac45048e74bc88d4fbeabcf7c5c122023-11-02T23:17:11ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-11-011411209215https://doi.org/10.3126/ajms.v14i11.56380The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East IndiaMausumi Mukherjee 0https://orcid.org/0000-0002-1717-028XSumon Poddar 1https://orcid.org/0000-0002-0358-7279Barnali Das 2https://orcid.org/0000-0003-4603-6191Amrita Mukherjee 3https://orcid.org/0009-0001-9800-1233Shubhojit Deysarkar 4https://orcid.org/0000-0001-6252-3729Madhura Mukherjee5https://orcid.org/0009-0001-6856-0261Assistant Professor, Department of Pediatric Medicine, Institute of Child Health, Kolkata, West Bengal, India Associate Professor and Head, Department of Microbiology, Institute of Child Health, Kolkata, West Bengal, India Assistant Professor, Department of Pediatric Medicine, Institute of Child Health, Kolkata, West Bengal, India Sixth Semester Batch, BA Economics, Department of Economics, St. Stephens College, Delhi University, Delhi, India Senior Resident, Department of Pediatrics, Institute of Child Health, Kolkata, West Bengal, India Junior Resident (Non-Academic), Critical Care Unit, IPGMER and SSKM Hospital, Kolkata, West Bengal, India Background: Coagulase-negative Staphylococcus (CoNS) are known commensals and often contaminate neonatal blood cultures. Their unique ability to form biofilms, however, helps them evade immune mechanisms and antibiotics and cause neonatal sepsis (NS) in hospitalized neonates. True or probable Coagulase-negative Staphylococcus blood stream infection (CoNS BSI) must be differentiated from contaminants so that antibiotics are used judiciously and hospital stay is minimized. Aims and Objectives: The primary objective of the study was to estimate the proportion of NS and contaminants among CoNS-positive blood cultures in the index neonatal unit and the host and health-care variables associated with CoNS BSI. The secondary objective was to estimate the susceptibility of CoNS isolates to antibiotics used. Materials and Methods: This was a retrospective study from digital records, from January 2018 to December 2022. Results: 25% of CoNS isolates were associated with NS (health-care infections) and 75% were contaminants. Over 90% of CoNS BSI was associated with central lines (CLs) and prolonged hospital stay. All isolates were resistant to oxacillin while resistance to gentamicin rose annually to over 68%. Susceptibility to linezolid and vancomycin was present, but a few strains were resistant to them. Conclusion: CoNS were an important cause of NS in the index hospital. Prolonged hospital stays and CLs were associated with increased incidence of CoNS sepsis and must be minimized where possible. Antibiotic resistance was high, and reserve drugs could also become ineffective.https://www.nepjol.info/index.php/AJMS/article/view/56380coagulase-negative staphylococcus; neonatal sepsis; contamination; polymicrobial sepsis |
| spellingShingle | Mausumi Mukherjee Sumon Poddar Barnali Das Amrita Mukherjee Shubhojit Deysarkar Madhura Mukherjee The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India Asian Journal of Medical Sciences coagulase-negative staphylococcus; neonatal sepsis; contamination; polymicrobial sepsis |
| title | The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India |
| title_full | The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India |
| title_fullStr | The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India |
| title_full_unstemmed | The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India |
| title_short | The relevance of coagulase-negative Staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from East India |
| title_sort | relevance of coagulase negative staphylococcus isolates in blood culture in the context of a tertiary neonatal unit from east india |
| topic | coagulase-negative staphylococcus; neonatal sepsis; contamination; polymicrobial sepsis |
| url | https://www.nepjol.info/index.php/AJMS/article/view/56380 |
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