Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study
Abstract Background Supporting people living with HIV using anti-retroviral therapy (ART) is important due to the requirement for strict medication adherence. To date, no data from longitudinal studies evaluating adherence by treatment-naïve people living with HIV are currently available. We investi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Pharmaceutical Health Care and Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40780-023-00277-y |
| _version_ | 1797864022424420352 |
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| author | Yusuke Sekine Takashi Kawaguchi Yusuke Kunimoto Junichi Masuda Ayako Numata Atsushi Hirano Hiroki Yagura Masashi Ishihara Shinichi Hikasa Mariko Tsukiji Tempei Miyaji Takuhiro Yamaguchi Ei Kinai Kagehiro Amano |
| author_facet | Yusuke Sekine Takashi Kawaguchi Yusuke Kunimoto Junichi Masuda Ayako Numata Atsushi Hirano Hiroki Yagura Masashi Ishihara Shinichi Hikasa Mariko Tsukiji Tempei Miyaji Takuhiro Yamaguchi Ei Kinai Kagehiro Amano |
| author_sort | Yusuke Sekine |
| collection | DOAJ |
| description | Abstract Background Supporting people living with HIV using anti-retroviral therapy (ART) is important due to the requirement for strict medication adherence. To date, no data from longitudinal studies evaluating adherence by treatment-naïve people living with HIV are currently available. We investigated the adherence of treatment-naïve people living with HIV over time and examined the relationships among decisional conflicts, adherence, and health-related quality of life (HRQL). Methods The survey items included adherence (visual analogue scale [VAS]), decisional conflict (decisional conflict scale [DCS]), and HRQL (Medical Outcomes Study HIV Health Survey [MOS-HIV]). The DCS and MOS-HIV scores and the VAS and MOS scores were collected electronically at the ART initiation time point and at 4-, 24-, and 48-week post-treatment time points. Results A total of 215 participants were enrolled. The mean DCS score was 27.3 (SD, 0.9); 23.3% of participants were in the high-score and 36.7% in the low-score groups. The mean adherence rates at 4, 24, and 48 weeks were 99.2% (standard error [SE], 0.2), 98.4% (SE, 0.4), and 96.0% (SE, 1.2), respectively. The least-square means of the MOS-HIV for the DCS (high vs. low scores) were 64.4 vs. 69.2 for general health perceptions and 57.7 vs. 64.0 for HRQL, respectively. Conclusion Adherence among treatment-naïve people living with HIV was maintained at a higher level, and HRQL tended to improve with ART. People with high levels of decisional conflict tended to have lower HRQL scores. Support for people living with HIV during ART initiation may be related to HRQL. |
| first_indexed | 2024-04-09T22:44:54Z |
| format | Article |
| id | doaj.art-73dae0918a5043aa97c4394c610203fe |
| institution | Directory Open Access Journal |
| issn | 2055-0294 |
| language | English |
| last_indexed | 2024-04-09T22:44:54Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Pharmaceutical Health Care and Sciences |
| spelling | doaj.art-73dae0918a5043aa97c4394c610203fe2023-03-22T11:54:43ZengBMCJournal of Pharmaceutical Health Care and Sciences2055-02942023-03-019111110.1186/s40780-023-00277-yAdherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational studyYusuke Sekine0Takashi Kawaguchi1Yusuke Kunimoto2Junichi Masuda3Ayako Numata4Atsushi Hirano5Hiroki Yagura6Masashi Ishihara7Shinichi Hikasa8Mariko Tsukiji9Tempei Miyaji10Takuhiro Yamaguchi11Ei Kinai12Kagehiro Amano13Department of Pharmacy, Tokyo Medical University HospitalDepartment of Practical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life SciencesDepartment of Pharmacy, Sapporo Medical University HospitalDepartment of Pharmacy, Center Hospital of the National Center for Global Health and MedicineDepartment of Pharmacy, Center Hospital of the National Center for Global Health and MedicineDepartment of Pharmacy, National Hospital organization Nagoya Medical CenterDepartment of Pharmacy, National Hospital Organization Osaka National HospitalDepartment of Pharmacy, Gifu University HospitalDepartment of Pharmacy, Hyogo Medical University HospitalDivision of Pharmacy, Chiba University HospitalDivision of Biostatistics, Tohoku University Graduate School of MedicineDivision of Biostatistics, Tohoku University Graduate School of MedicineDepartment of Laboratory Medicine, Tokyo Medical UniversityDepartment of Laboratory Medicine, Tokyo Medical UniversityAbstract Background Supporting people living with HIV using anti-retroviral therapy (ART) is important due to the requirement for strict medication adherence. To date, no data from longitudinal studies evaluating adherence by treatment-naïve people living with HIV are currently available. We investigated the adherence of treatment-naïve people living with HIV over time and examined the relationships among decisional conflicts, adherence, and health-related quality of life (HRQL). Methods The survey items included adherence (visual analogue scale [VAS]), decisional conflict (decisional conflict scale [DCS]), and HRQL (Medical Outcomes Study HIV Health Survey [MOS-HIV]). The DCS and MOS-HIV scores and the VAS and MOS scores were collected electronically at the ART initiation time point and at 4-, 24-, and 48-week post-treatment time points. Results A total of 215 participants were enrolled. The mean DCS score was 27.3 (SD, 0.9); 23.3% of participants were in the high-score and 36.7% in the low-score groups. The mean adherence rates at 4, 24, and 48 weeks were 99.2% (standard error [SE], 0.2), 98.4% (SE, 0.4), and 96.0% (SE, 1.2), respectively. The least-square means of the MOS-HIV for the DCS (high vs. low scores) were 64.4 vs. 69.2 for general health perceptions and 57.7 vs. 64.0 for HRQL, respectively. Conclusion Adherence among treatment-naïve people living with HIV was maintained at a higher level, and HRQL tended to improve with ART. People with high levels of decisional conflict tended to have lower HRQL scores. Support for people living with HIV during ART initiation may be related to HRQL.https://doi.org/10.1186/s40780-023-00277-yTreatment-naïve people living with HIVAnti-retroviral therapyDecisional conflictAdherenceHealth-related quality of life |
| spellingShingle | Yusuke Sekine Takashi Kawaguchi Yusuke Kunimoto Junichi Masuda Ayako Numata Atsushi Hirano Hiroki Yagura Masashi Ishihara Shinichi Hikasa Mariko Tsukiji Tempei Miyaji Takuhiro Yamaguchi Ei Kinai Kagehiro Amano Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study Journal of Pharmaceutical Health Care and Sciences Treatment-naïve people living with HIV Anti-retroviral therapy Decisional conflict Adherence Health-related quality of life |
| title | Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study |
| title_full | Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study |
| title_fullStr | Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study |
| title_full_unstemmed | Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study |
| title_short | Adherence to anti-retroviral therapy, decisional conflicts, and health-related quality of life among treatment-naïve individuals living with HIV: a DEARS-J observational study |
| title_sort | adherence to anti retroviral therapy decisional conflicts and health related quality of life among treatment naive individuals living with hiv a dears j observational study |
| topic | Treatment-naïve people living with HIV Anti-retroviral therapy Decisional conflict Adherence Health-related quality of life |
| url | https://doi.org/10.1186/s40780-023-00277-y |
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