Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

Abstract Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current mRNA delivery platforms need to be stored at −20 °C or −70 °C due to their poor stability, which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-...

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Bibliographic Details
Main Authors: Liangxia Ai, Yafei Li, Li Zhou, Wenrong Yao, Hao Zhang, Zhaoyu Hu, Jinyu Han, Weijie Wang, Junmiao Wu, Pan Xu, Ruiyue Wang, Zhangyi Li, Zhouwang Li, Chengliang Wei, Jianqun Liang, Haobo Chen, Zhimiao Yang, Ming Guo, Zhixiang Huang, Xin Wang, Zhen Zhang, Wenjie Xiang, Dazheng Sun, Lianqiang Xu, Meiyan Huang, Bin Lv, Peiqi Peng, Shangfeng Zhang, Xuhao Ji, Huiyi Luo, Nanping Chen, Jianping Chen, Ke Lan, Yong Hu
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00517-9

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