The Role of Genetics in the Management of Heart Failure Patients
Over the last decades, the relevance of genetics in cardiovascular diseases has expanded, especially in the context of cardiomyopathies. Its relevance extends to the management of patients diagnosed with heart failure (HF), given its capacity to provide invaluable insights into the etiology of cardi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/20/15221 |
| _version_ | 1797573629145251840 |
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| author | Gianpaolo Palmieri Maria Francesca D’Ambrosio Michele Correale Natale Daniele Brunetti Rosa Santacroce Massimo Iacoviello Maurizio Margaglione |
| author_facet | Gianpaolo Palmieri Maria Francesca D’Ambrosio Michele Correale Natale Daniele Brunetti Rosa Santacroce Massimo Iacoviello Maurizio Margaglione |
| author_sort | Gianpaolo Palmieri |
| collection | DOAJ |
| description | Over the last decades, the relevance of genetics in cardiovascular diseases has expanded, especially in the context of cardiomyopathies. Its relevance extends to the management of patients diagnosed with heart failure (HF), given its capacity to provide invaluable insights into the etiology of cardiomyopathies and identify individuals at a heightened risk of poor outcomes. Notably, the identification of an etiological genetic variant necessitates a comprehensive evaluation of the family lineage of the affected patients. In the future, these genetic variants hold potential as therapeutic targets with the capability to modify gene expression. In this complex setting, collaboration among cardiologists, specifically those specializing in cardiomyopathies and HF, and geneticists becomes paramount to improving individual and family health outcomes, as well as therapeutic clinical results. This review is intended to offer geneticists and cardiologists an updated perspective on the value of genetic research in HF and its implications in clinical practice. |
| first_indexed | 2024-03-10T21:11:50Z |
| format | Article |
| id | doaj.art-73db3806884345869cce2dab387f457d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:11:50Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-73db3806884345869cce2dab387f457d2023-11-19T16:43:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201522110.3390/ijms242015221The Role of Genetics in the Management of Heart Failure PatientsGianpaolo Palmieri0Maria Francesca D’Ambrosio1Michele Correale2Natale Daniele Brunetti3Rosa Santacroce4Massimo Iacoviello5Maurizio Margaglione6School of Cardiology, Department of Medical and Surgical Sciences, University of Foggia, 70122 Foggia, ItalyMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, 70122 Foggia, ItalySchool of Cardiology, Department of Medical and Surgical Sciences, University of Foggia, 70122 Foggia, ItalySchool of Cardiology, Department of Medical and Surgical Sciences, University of Foggia, 70122 Foggia, ItalyMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, 70122 Foggia, ItalyUniversity Cardiology Unit, Polyclinic Hospital of Bari, 70124 Bari, ItalyMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, 70122 Foggia, ItalyOver the last decades, the relevance of genetics in cardiovascular diseases has expanded, especially in the context of cardiomyopathies. Its relevance extends to the management of patients diagnosed with heart failure (HF), given its capacity to provide invaluable insights into the etiology of cardiomyopathies and identify individuals at a heightened risk of poor outcomes. Notably, the identification of an etiological genetic variant necessitates a comprehensive evaluation of the family lineage of the affected patients. In the future, these genetic variants hold potential as therapeutic targets with the capability to modify gene expression. In this complex setting, collaboration among cardiologists, specifically those specializing in cardiomyopathies and HF, and geneticists becomes paramount to improving individual and family health outcomes, as well as therapeutic clinical results. This review is intended to offer geneticists and cardiologists an updated perspective on the value of genetic research in HF and its implications in clinical practice.https://www.mdpi.com/1422-0067/24/20/15221heart failuregeneticsdiagnosisprognosistherapy |
| spellingShingle | Gianpaolo Palmieri Maria Francesca D’Ambrosio Michele Correale Natale Daniele Brunetti Rosa Santacroce Massimo Iacoviello Maurizio Margaglione The Role of Genetics in the Management of Heart Failure Patients International Journal of Molecular Sciences heart failure genetics diagnosis prognosis therapy |
| title | The Role of Genetics in the Management of Heart Failure Patients |
| title_full | The Role of Genetics in the Management of Heart Failure Patients |
| title_fullStr | The Role of Genetics in the Management of Heart Failure Patients |
| title_full_unstemmed | The Role of Genetics in the Management of Heart Failure Patients |
| title_short | The Role of Genetics in the Management of Heart Failure Patients |
| title_sort | role of genetics in the management of heart failure patients |
| topic | heart failure genetics diagnosis prognosis therapy |
| url | https://www.mdpi.com/1422-0067/24/20/15221 |
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