Molecular genetic markers of breast cancer
Breast cancer (BC) is the second most common type of cancer worldwide and affects 1 in 8 women over the course of their lifetime. A personalized approach to treating BC can substantially increase efficiency and consequently maintain the active life of many people. This encourages investigators and p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-11-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/506 |
| _version_ | 1797876009989570560 |
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| author | K. A. Grishina T. A. Muzaffarova V. A. Khaylenko A. V. Karpukhin |
| author_facet | K. A. Grishina T. A. Muzaffarova V. A. Khaylenko A. V. Karpukhin |
| author_sort | K. A. Grishina |
| collection | DOAJ |
| description | Breast cancer (BC) is the second most common type of cancer worldwide and affects 1 in 8 women over the course of their lifetime. A personalized approach to treating BC can substantially increase efficiency and consequently maintain the active life of many people. This encourages investigators and physicians to better understand tumor biology in order to make a correct diagnosis, to determine recurrence risk, and to choose adequate therapy. This paper discusses the bases for the molecular classification of BC into its expression subtypes, as well as current prognostic kits that assist oncologists in classifying the subtypes of cancer and in predicting the development of the disease. The existing test systems are not universal, each of them is applicable only to a limited group of patients, but they totally cover a considerable number of cases. The tumor gene mutations in BC, which have been characterized by up-to-date methods, can serve as predictive markers for the efficiency of targeted therapy. |
| first_indexed | 2024-04-10T01:56:31Z |
| format | Article |
| id | doaj.art-73dbdc8b2d274a31a7c0cc9abcb5b61e |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:56:31Z |
| publishDate | 2016-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-73dbdc8b2d274a31a7c0cc9abcb5b61e2023-03-13T08:44:36ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272016-11-01123364210.17650/1994-4098-2016-12-3-36-42508Molecular genetic markers of breast cancerK. A. Grishina0T. A. Muzaffarova1V. A. Khaylenko2A. V. Karpukhin3ФГБНУ «Медико-генетический научный центр»ФГБНУ «Медико-генетический научный центр»ФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава РоссииФГБНУ «Медико-генетический научный центр»Breast cancer (BC) is the second most common type of cancer worldwide and affects 1 in 8 women over the course of their lifetime. A personalized approach to treating BC can substantially increase efficiency and consequently maintain the active life of many people. This encourages investigators and physicians to better understand tumor biology in order to make a correct diagnosis, to determine recurrence risk, and to choose adequate therapy. This paper discusses the bases for the molecular classification of BC into its expression subtypes, as well as current prognostic kits that assist oncologists in classifying the subtypes of cancer and in predicting the development of the disease. The existing test systems are not universal, each of them is applicable only to a limited group of patients, but they totally cover a considerable number of cases. The tumor gene mutations in BC, which have been characterized by up-to-date methods, can serve as predictive markers for the efficiency of targeted therapy.https://ojrs.abvpress.ru/ojrs/article/view/506рак молочной железымолекулярная классификацияэкспрессионные подтипысовременные прогностические системымутации |
| spellingShingle | K. A. Grishina T. A. Muzaffarova V. A. Khaylenko A. V. Karpukhin Molecular genetic markers of breast cancer Опухоли женской репродуктивной системы рак молочной железы молекулярная классификация экспрессионные подтипы современные прогностические системы мутации |
| title | Molecular genetic markers of breast cancer |
| title_full | Molecular genetic markers of breast cancer |
| title_fullStr | Molecular genetic markers of breast cancer |
| title_full_unstemmed | Molecular genetic markers of breast cancer |
| title_short | Molecular genetic markers of breast cancer |
| title_sort | molecular genetic markers of breast cancer |
| topic | рак молочной железы молекулярная классификация экспрессионные подтипы современные прогностические системы мутации |
| url | https://ojrs.abvpress.ru/ojrs/article/view/506 |
| work_keys_str_mv | AT kagrishina moleculargeneticmarkersofbreastcancer AT tamuzaffarova moleculargeneticmarkersofbreastcancer AT vakhaylenko moleculargeneticmarkersofbreastcancer AT avkarpukhin moleculargeneticmarkersofbreastcancer |