Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals
The abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with those of protein-coding genes for which a larg...
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MDPI AG
2016-07-01
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| Series: | Life |
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| Online Access: | http://www.mdpi.com/2075-1729/6/3/27 |
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| author | Diana Chernikova David Managadze Galina V. Glazko Wojciech Makalowski Igor B. Rogozin |
| author_facet | Diana Chernikova David Managadze Galina V. Glazko Wojciech Makalowski Igor B. Rogozin |
| author_sort | Diana Chernikova |
| collection | DOAJ |
| description | The abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with those of protein-coding genes for which a large body of functional information is available. A prominent feature of mammalian protein-coding genes is the high evolutionary conservation of the exon-intron structure. Comparative analysis of putative intron positions in lincRNA genes from various mammalian genomes suggests that some lincRNA introns have been conserved for over 100 million years, thus the primary and/or secondary structure of these molecules is likely to be functionally important. |
| first_indexed | 2024-04-14T03:21:54Z |
| format | Article |
| id | doaj.art-73defe2ea0b340429f366e74edf1e11a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-04-14T03:21:54Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj.art-73defe2ea0b340429f366e74edf1e11a2022-12-22T02:15:17ZengMDPI AGLife2075-17292016-07-01632710.3390/life6030027life6030027Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian MammalsDiana Chernikova0David Managadze1Galina V. Glazko2Wojciech Makalowski3Igor B. Rogozin4Department of Genetics, Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USAInformation Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USADepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAInstitute of Bioinformatics, University of Muenster, Muenster 48149, GermanyComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USAThe abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with those of protein-coding genes for which a large body of functional information is available. A prominent feature of mammalian protein-coding genes is the high evolutionary conservation of the exon-intron structure. Comparative analysis of putative intron positions in lincRNA genes from various mammalian genomes suggests that some lincRNA introns have been conserved for over 100 million years, thus the primary and/or secondary structure of these molecules is likely to be functionally important.http://www.mdpi.com/2075-1729/6/3/27lincRNAexonintronnon-coding RNAgenomic alignmentsintron gainintron loss |
| spellingShingle | Diana Chernikova David Managadze Galina V. Glazko Wojciech Makalowski Igor B. Rogozin Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals Life lincRNA exon intron non-coding RNA genomic alignments intron gain intron loss |
| title | Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals |
| title_full | Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals |
| title_fullStr | Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals |
| title_full_unstemmed | Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals |
| title_short | Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals |
| title_sort | conservation of the exon intron structure of long intergenic non coding rna genes in eutherian mammals |
| topic | lincRNA exon intron non-coding RNA genomic alignments intron gain intron loss |
| url | http://www.mdpi.com/2075-1729/6/3/27 |
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