CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT
Introduction: Chorioretinal coloboma (CRC) results from abnormal closure of the embryonic fissure. Choroidal neovascularization (CNV) is a rare complication that associated with coloboma of the choroid. VEGF is an important factor in the development of CNV. Case Report: A 52-year-old woman with...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Journal of Retina
2022-09-01
|
| Series: | IJRETINA (International Journal of Retina) |
| Online Access: | https://www.ijretina.com/index.php/ijretina/article/view/124 |
| _version_ | 1811174315493687296 |
|---|---|
| author | Dicky Budiman Simanjuntak Andi Arus Victor Gitalisa Andayani |
| author_facet | Dicky Budiman Simanjuntak Andi Arus Victor Gitalisa Andayani |
| author_sort | Dicky Budiman Simanjuntak |
| collection | DOAJ |
| description |
Introduction: Chorioretinal coloboma (CRC) results from abnormal closure of the embryonic fissure. Choroidal neovascularization (CNV) is a rare complication that associated with coloboma of the choroid. VEGF is an important factor in the development of CNV.
Case Report: A 52-year-old woman with gradual blurred vision of the left eye since 4 months ago. Right eye was already blurred since she was a child with uncorrected visual acuity (UCVA) was 0.5/60. Her right iris showed coloboma in inferior and chorioretinal coloboma. UCVA of the left eye was 6/20. Her left iris showed inferior coloboma, chorioretinal coloboma and macular edema with soft drusen. Macular optical coherence tomography (OCT) confirmed macular subretinal fluid, and indicated a CNV lesion of the left eye. She underwent a loading dose of three monthly intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections (bevacizumab) for the left eye. One month after completion of treatment, UCVA of the left eye improved to 6/12.
Discussion: CNV is a complication associated with CRC. Intravitreal Anti-VEGF treatment using loading dose regimen is shown to be effective in treating CNV. One month after completion of treatment, UCVA of the left eye improved.
Conclusion: Chorioretinal coloboma is a rare posterior segment congenital anomaly. Classical, bilateral coloboma of the choroid and iris indicates a deformation of the choroidal fissure closure. Coloboma of the choroid can have a complication such as choroidal neovascularization. Treatment with a loading dose of three monthly intravitreal anti-VEGF injections showed good anatomical and functional results.
|
| first_indexed | 2024-04-10T19:18:19Z |
| format | Article |
| id | doaj.art-73df5fefdd2c4302a6d0ad481c2a584a |
| institution | Directory Open Access Journal |
| issn | 2614-8684 2614-8536 |
| language | English |
| last_indexed | 2024-04-10T19:18:19Z |
| publishDate | 2022-09-01 |
| publisher | International Journal of Retina |
| record_format | Article |
| series | IJRETINA (International Journal of Retina) |
| spelling | doaj.art-73df5fefdd2c4302a6d0ad481c2a584a2023-01-30T10:00:34ZengInternational Journal of RetinaIJRETINA (International Journal of Retina)2614-86842614-85362022-09-015210.35479/ijretina.2022.vol005.iss002.124 CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORTDicky Budiman Simanjuntak0Andi Arus Victor1Gitalisa Andayani2Faculty of medicine University of IndonesiaFaculty of Medicine Universitas IndonesiaOphthalmology Department, Faculty of Medicine Universitas Indonesia- Dr Cipto Mangunkusumo Hospital, Jakarta Indonesia Introduction: Chorioretinal coloboma (CRC) results from abnormal closure of the embryonic fissure. Choroidal neovascularization (CNV) is a rare complication that associated with coloboma of the choroid. VEGF is an important factor in the development of CNV. Case Report: A 52-year-old woman with gradual blurred vision of the left eye since 4 months ago. Right eye was already blurred since she was a child with uncorrected visual acuity (UCVA) was 0.5/60. Her right iris showed coloboma in inferior and chorioretinal coloboma. UCVA of the left eye was 6/20. Her left iris showed inferior coloboma, chorioretinal coloboma and macular edema with soft drusen. Macular optical coherence tomography (OCT) confirmed macular subretinal fluid, and indicated a CNV lesion of the left eye. She underwent a loading dose of three monthly intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections (bevacizumab) for the left eye. One month after completion of treatment, UCVA of the left eye improved to 6/12. Discussion: CNV is a complication associated with CRC. Intravitreal Anti-VEGF treatment using loading dose regimen is shown to be effective in treating CNV. One month after completion of treatment, UCVA of the left eye improved. Conclusion: Chorioretinal coloboma is a rare posterior segment congenital anomaly. Classical, bilateral coloboma of the choroid and iris indicates a deformation of the choroidal fissure closure. Coloboma of the choroid can have a complication such as choroidal neovascularization. Treatment with a loading dose of three monthly intravitreal anti-VEGF injections showed good anatomical and functional results. https://www.ijretina.com/index.php/ijretina/article/view/124 |
| spellingShingle | Dicky Budiman Simanjuntak Andi Arus Victor Gitalisa Andayani CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT IJRETINA (International Journal of Retina) |
| title | CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT |
| title_full | CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT |
| title_fullStr | CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT |
| title_full_unstemmed | CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT |
| title_short | CHOROIDAL NEOVASCULARIZATION IN A CASE OF CHORIORETINAL COLOBOMA TREATED WITH INTRAVITREAL ANTI-VEGF INJECTONS: A CASE REPORT |
| title_sort | choroidal neovascularization in a case of chorioretinal coloboma treated with intravitreal anti vegf injectons a case report |
| url | https://www.ijretina.com/index.php/ijretina/article/view/124 |
| work_keys_str_mv | AT dickybudimansimanjuntak choroidalneovascularizationinacaseofchorioretinalcolobomatreatedwithintravitrealantivegfinjectonsacasereport AT andiarusvictor choroidalneovascularizationinacaseofchorioretinalcolobomatreatedwithintravitrealantivegfinjectonsacasereport AT gitalisaandayani choroidalneovascularizationinacaseofchorioretinalcolobomatreatedwithintravitrealantivegfinjectonsacasereport |