The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.

The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.

Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In vivo, interleukin-4 (IL-4)-mediated signaling via IL-4 receptor alpha (IL-4Rα) mediates Treg cell transdifferentiation into ex-Foxp3 T helpe...

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Bibliographic Details
Main Authors:	Nada Abdel Aziz, Justin Komguep Nono, Thabo Mpotje, Frank Brombacher
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-10-01
Series:	PLoS Biology
Online Access:	https://doi.org/10.1371/journal.pbio.2005850

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