Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income.
BACKGROUND: Postmastectomy breast reconstruction is widely used in breast cancer patients for its aesthetic effect. Although several studies have casted suspicion upon the oncological safety of immediate breast reconstruction after mastectomy, the potential impact of different reconstruction methods...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3861449?pdf=render |
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| author | Yi-Zhou Jiang Yi-Rong Liu Ke-Da Yu Wen-Jia Zuo Zhi-Ming Shao |
| author_facet | Yi-Zhou Jiang Yi-Rong Liu Ke-Da Yu Wen-Jia Zuo Zhi-Ming Shao |
| author_sort | Yi-Zhou Jiang |
| collection | DOAJ |
| description | BACKGROUND: Postmastectomy breast reconstruction is widely used in breast cancer patients for its aesthetic effect. Although several studies have casted suspicion upon the oncological safety of immediate breast reconstruction after mastectomy, the potential impact of different reconstruction methods on patient survival remains unclear. PATIENTS AND METHODS: We identified 35,126 female patients diagnosed with breast cancer from January 1, 1998 to December 31, 2002 in the Surveillance, Epidemiology, and End Results database. Breast cancer-specific survival (BCSS) and overall survival (OS) were compared among patients who underwent mastectomy with or without immediate breast reconstruction (autologous reconstruction or implant reconstruction) using Cox proportional hazard regression models. RESULTS: In multivariate analysis unadjusted for family income, patients undergoing immediate postmastectomy reconstruction exhibited improved BCSS [POOLED reconstruction (any types of reconstruction): hazard ratio (HR) = 0.87, 95% confidence interval (CI) 0.80-0.95, P = 0.001] and OS (pooled reconstruction: HR = 0.70, 95% CI 0.65-0.75, P<0.001) compared to patients who underwent mastectomy alone. However, after stratifying by family income, patients receiving reconstruction showed limited advantage in BCSS and OS compared with those undergoing mastectomy alone. When comparing between the two reconstruction methods, no significant differences were observed in either BCSS (implant versus autologous reconstruction: HR = 1.11, 95%CI 0.90-1.35, P = 0.330) or OS (implant versus autologous reconstruction: HR = 1.07, 95% 0.90-1.28, P = 0.424). CONCLUSIONS: Compared to mastectomy alone, immediate postmastectomy reconstruction had limited advantage in survival after adjusting for confounding factor of family income. Our findings, if validated in other large databases, may help to illustrate the actual effect of immediate postmastectomy reconstruction on patient survival. |
| first_indexed | 2024-12-11T18:21:35Z |
| format | Article |
| id | doaj.art-73e07270333846a6bc6f504bfaba2ea0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T18:21:35Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-73e07270333846a6bc6f504bfaba2ea02022-12-22T00:55:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8280710.1371/journal.pone.0082807Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income.Yi-Zhou JiangYi-Rong LiuKe-Da YuWen-Jia ZuoZhi-Ming ShaoBACKGROUND: Postmastectomy breast reconstruction is widely used in breast cancer patients for its aesthetic effect. Although several studies have casted suspicion upon the oncological safety of immediate breast reconstruction after mastectomy, the potential impact of different reconstruction methods on patient survival remains unclear. PATIENTS AND METHODS: We identified 35,126 female patients diagnosed with breast cancer from January 1, 1998 to December 31, 2002 in the Surveillance, Epidemiology, and End Results database. Breast cancer-specific survival (BCSS) and overall survival (OS) were compared among patients who underwent mastectomy with or without immediate breast reconstruction (autologous reconstruction or implant reconstruction) using Cox proportional hazard regression models. RESULTS: In multivariate analysis unadjusted for family income, patients undergoing immediate postmastectomy reconstruction exhibited improved BCSS [POOLED reconstruction (any types of reconstruction): hazard ratio (HR) = 0.87, 95% confidence interval (CI) 0.80-0.95, P = 0.001] and OS (pooled reconstruction: HR = 0.70, 95% CI 0.65-0.75, P<0.001) compared to patients who underwent mastectomy alone. However, after stratifying by family income, patients receiving reconstruction showed limited advantage in BCSS and OS compared with those undergoing mastectomy alone. When comparing between the two reconstruction methods, no significant differences were observed in either BCSS (implant versus autologous reconstruction: HR = 1.11, 95%CI 0.90-1.35, P = 0.330) or OS (implant versus autologous reconstruction: HR = 1.07, 95% 0.90-1.28, P = 0.424). CONCLUSIONS: Compared to mastectomy alone, immediate postmastectomy reconstruction had limited advantage in survival after adjusting for confounding factor of family income. Our findings, if validated in other large databases, may help to illustrate the actual effect of immediate postmastectomy reconstruction on patient survival.http://europepmc.org/articles/PMC3861449?pdf=render |
| spellingShingle | Yi-Zhou Jiang Yi-Rong Liu Ke-Da Yu Wen-Jia Zuo Zhi-Ming Shao Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. PLoS ONE |
| title | Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. |
| title_full | Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. |
| title_fullStr | Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. |
| title_full_unstemmed | Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. |
| title_short | Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income. |
| title_sort | immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income |
| url | http://europepmc.org/articles/PMC3861449?pdf=render |
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