Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat
Background: Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants an...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Institue of Medicinal Plants, ACECR
2010-03-01
|
| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-516-en.html |
| _version_ | 1818602096396599296 |
|---|---|
| author | AA Khaki A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh D Babazadeh A Zahedi Z Ghanbari |
| author_facet | AA Khaki A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh D Babazadeh A Zahedi Z Ghanbari |
| author_sort | AA Khaki |
| collection | DOAJ |
| description | Background: Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants and long-term treatment of Streptozotocin induced–diabetic animals with these herbs, has been shown to reduce oxidative stress.
Objective: Evaluation to treatment effect of Ginger rhizome and extract of carrot seed on nephropathy after diabetes inducement.
Methods: Wistar male rat (n=70) were allocated into seven groups, control group, carrot seed extract group, ginger group, control- Diabetic group received 55mg/kg (IP) streptozotocin (STZ), treatment diabetic group that received carrot seed extract, treatment diabetic group that received ginger and treatment diabetic group that received carrot seed extract plus ginger. Animals were kept in standard condition. In 30 day after inducing diabetes, 5ml blood were collected for analyzing of TAC and MDA levels, and kidney tissues of Rats were removed in all groups then prepared for analysis.
Results: Pathological changes in diabetic group which received carrot seed and ginger together was decreased compared to control group. The rate of serum TAC significantly increased in diabetic groups which received carrot seed and ginger together significantly in comparison to control-diabetic group (p<0.05).
Conclusion: Since in our study 25 mg/kg carrot seed extract and 100 mg/kg ginger have prevented kidney tissue injury by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for treatment nephropathy in Diabetic rats. |
| first_indexed | 2024-12-16T13:01:51Z |
| format | Article |
| id | doaj.art-73e23b3c51b84e929b5232e8424e1afc |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-16T13:01:51Z |
| publishDate | 2010-03-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-73e23b3c51b84e929b5232e8424e1afc2022-12-21T22:30:48ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582010-03-019337580Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in RatAA Khaki0A Khaki1HR Ahmadi-Ashtiani2H Rastegar3Sh Rezazadeh4D Babazadeh5A Zahedi6Z Ghanbari7 Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran & Biochemistry and Nutrition Department of Zanjan Medical University, Zanjan Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran Institute of Medicinal Plants, ACECR, Tehran Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab Department of Veterinary Pathology, Islamic Azad University, Rasht Branch, Rasht Medical school of Islamic Azad University, Tabriz Branch, Tabriz Background: Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants and long-term treatment of Streptozotocin induced–diabetic animals with these herbs, has been shown to reduce oxidative stress. Objective: Evaluation to treatment effect of Ginger rhizome and extract of carrot seed on nephropathy after diabetes inducement. Methods: Wistar male rat (n=70) were allocated into seven groups, control group, carrot seed extract group, ginger group, control- Diabetic group received 55mg/kg (IP) streptozotocin (STZ), treatment diabetic group that received carrot seed extract, treatment diabetic group that received ginger and treatment diabetic group that received carrot seed extract plus ginger. Animals were kept in standard condition. In 30 day after inducing diabetes, 5ml blood were collected for analyzing of TAC and MDA levels, and kidney tissues of Rats were removed in all groups then prepared for analysis. Results: Pathological changes in diabetic group which received carrot seed and ginger together was decreased compared to control group. The rate of serum TAC significantly increased in diabetic groups which received carrot seed and ginger together significantly in comparison to control-diabetic group (p<0.05). Conclusion: Since in our study 25 mg/kg carrot seed extract and 100 mg/kg ginger have prevented kidney tissue injury by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for treatment nephropathy in Diabetic rats.http://jmp.ir/article-1-516-en.htmlcarrot seedgingernephropathydiabetic rats |
| spellingShingle | AA Khaki A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh D Babazadeh A Zahedi Z Ghanbari Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat Journal of Medicinal Plants carrot seed ginger nephropathy diabetic rats |
| title | Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat |
| title_full | Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat |
| title_fullStr | Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat |
| title_full_unstemmed | Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat |
| title_short | Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat |
| title_sort | treatment effects of ginger rhizome extract of carrot seed on diabetic nephropathy in rat |
| topic | carrot seed ginger nephropathy diabetic rats |
| url | http://jmp.ir/article-1-516-en.html |
| work_keys_str_mv | AT aakhaki treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT akhaki treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT hrahmadiashtiani treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT hrastegar treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT shrezazadeh treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT dbabazadeh treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT azahedi treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat AT zghanbari treatmenteffectsofgingerrhizomeextractofcarrotseedondiabeticnephropathyinrat |