The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study
The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation of the scaffolds as well as new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves the corrosion resistance of mag...
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KeAi Communications Co., Ltd.
2023-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23001901 |
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| author | Chaoxin Wang Jinge Liu Shuyuan Min Yu Liu Bingchuan Liu Yuanyu Hu Zhengguang Wang Fengbiao Mao Caimei Wang Xiaolin Ma Peng Wen Yufeng Zheng Yun Tian |
| author_facet | Chaoxin Wang Jinge Liu Shuyuan Min Yu Liu Bingchuan Liu Yuanyu Hu Zhengguang Wang Fengbiao Mao Caimei Wang Xiaolin Ma Peng Wen Yufeng Zheng Yun Tian |
| author_sort | Chaoxin Wang |
| collection | DOAJ |
| description | The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation of the scaffolds as well as new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves the corrosion resistance of magnesium scaffold. And the effects of pore size on the mechanical characteristics and biodegradation of scaffolds, as well as new bone formation, were investigated using magnesium scaffolds with three different pore sizes, namely, 500, 800, and 1400 μm (P500, P800, and P1400). We discovered that the mechanical characteristics of the P500 group were much better than those of the other two groups. In vitro and in vivo investigations showed that WE43 magnesium alloy scaffolds supported the survival of mesenchymal stem cells and did not cause any local toxicity. Due to their larger specific surface area, the scaffolds in the P500 group released more magnesium ions within reasonable range and improved the osteogenic differentiation of bone mesenchymal stem cells compared with the other two scaffolds. In a rabbit femoral condyle defect model, the P500 group demonstrated unique performance in promoting new bone formation, indicating its great potential for use in bone defect regeneration therapy. |
| first_indexed | 2024-03-12T22:03:06Z |
| format | Article |
| id | doaj.art-73e314bf106140c898c52b16c012abbf |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-03-12T22:03:06Z |
| publishDate | 2023-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-73e314bf106140c898c52b16c012abbf2023-07-25T04:15:23ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-10-0128537548The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo studyChaoxin Wang0Jinge Liu1Shuyuan Min2Yu Liu3Bingchuan Liu4Yuanyu Hu5Zhengguang Wang6Fengbiao Mao7Caimei Wang8Xiaolin Ma9Peng Wen10Yufeng Zheng11Yun Tian12Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaDepartment of Mechanical Engineering, Tsinghua University, Beijing, 100084, ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, ChinaInstitute of Medicine Innovation and Research, Peking University Third Hospital, Beijing, 100191, ChinaBeijing AKEC Medical Co., Ltd., Beijing, 102200, ChinaBeijing AKEC Medical Co., Ltd., Beijing, 102200, ChinaDepartment of Mechanical Engineering, Tsinghua University, Beijing, 100084, China; Corresponding author.School of Materials Science and Engineering, Peking University, Beijing, 100871, China; Corresponding author.Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, China; Corresponding author. Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China.The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation of the scaffolds as well as new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves the corrosion resistance of magnesium scaffold. And the effects of pore size on the mechanical characteristics and biodegradation of scaffolds, as well as new bone formation, were investigated using magnesium scaffolds with three different pore sizes, namely, 500, 800, and 1400 μm (P500, P800, and P1400). We discovered that the mechanical characteristics of the P500 group were much better than those of the other two groups. In vitro and in vivo investigations showed that WE43 magnesium alloy scaffolds supported the survival of mesenchymal stem cells and did not cause any local toxicity. Due to their larger specific surface area, the scaffolds in the P500 group released more magnesium ions within reasonable range and improved the osteogenic differentiation of bone mesenchymal stem cells compared with the other two scaffolds. In a rabbit femoral condyle defect model, the P500 group demonstrated unique performance in promoting new bone formation, indicating its great potential for use in bone defect regeneration therapy.http://www.sciencedirect.com/science/article/pii/S2452199X23001901Pore sizeAdditive manufacturingWE43 alloyMagnesium alloy |
| spellingShingle | Chaoxin Wang Jinge Liu Shuyuan Min Yu Liu Bingchuan Liu Yuanyu Hu Zhengguang Wang Fengbiao Mao Caimei Wang Xiaolin Ma Peng Wen Yufeng Zheng Yun Tian The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study Bioactive Materials Pore size Additive manufacturing WE43 alloy Magnesium alloy |
| title | The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study |
| title_full | The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study |
| title_fullStr | The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study |
| title_full_unstemmed | The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study |
| title_short | The effect of pore size on the mechanical properties, biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation: An in vitro and in vivo study |
| title_sort | effect of pore size on the mechanical properties biodegradation and osteogenic effects of additively manufactured magnesium scaffolds after high temperature oxidation an in vitro and in vivo study |
| topic | Pore size Additive manufacturing WE43 alloy Magnesium alloy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23001901 |
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