The Impact of Onset Age on Eosinophils in Kawasaki Disease
(1) Background: Kawasaki disease (KD) mainly affects children under the age of 5 years and eosinophilia in KD patients might be associated with the development of allergic diseases. We compared the age-adjusted Z-score (Z) of eosinophils and aimed to evaluate the impact of onset age on eosinophils i...
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/835 |
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| author | Yu-Jhen Chen Mindy Ming-Huey Guo Ling-Sai Chang Ho-Chang Kuo |
| author_facet | Yu-Jhen Chen Mindy Ming-Huey Guo Ling-Sai Chang Ho-Chang Kuo |
| author_sort | Yu-Jhen Chen |
| collection | DOAJ |
| description | (1) Background: Kawasaki disease (KD) mainly affects children under the age of 5 years and eosinophilia in KD patients might be associated with the development of allergic diseases. We compared the age-adjusted Z-score (Z) of eosinophils and aimed to evaluate the impact of onset age on eosinophils in KD patients. (2) Methods: We divided 398 KD patients into seven age subgroups. Laboratory data and the age-adjusted Z-score of eosinophils during the phases of Kawasaki disease were analyzed. (3) Results: The absolute eosinophil count among all age groups showed significant differences in the post-intravenous immunoglobulin (IVIG) phase and throughout the course of KD with Z-score adjusted for age. Further analysis showed persistent elevation of the age-adjusted Z-score of eosinophils (Z-eosinophil) especially in the under six-month-old age subgroup. In addition, we divided the Z-eosinophil into two groups to find the relationship with coronary artery lesions (CALs). Patients with a higher eosinophil count than average age values had a higher risk of developing CALs, while those with a lower eosinophil count than average age values had a lower risk of having CALs. (4) Conclusions: These findings may provide information to clinicians to pay attention to allergic diseases during the follow-up of KD, especially for children who are younger than 6 months old at the onset of KD, and eosinophil count could be a crucial focus in KD. |
| first_indexed | 2024-03-09T11:07:11Z |
| format | Article |
| id | doaj.art-73e37cbd6b1946589aba89954f9838ed |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:07:11Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-73e37cbd6b1946589aba89954f9838ed2023-12-01T00:54:04ZengMDPI AGBiomedicines2227-90592022-04-0110483510.3390/biomedicines10040835The Impact of Onset Age on Eosinophils in Kawasaki DiseaseYu-Jhen Chen0Mindy Ming-Huey Guo1Ling-Sai Chang2Ho-Chang Kuo3Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan(1) Background: Kawasaki disease (KD) mainly affects children under the age of 5 years and eosinophilia in KD patients might be associated with the development of allergic diseases. We compared the age-adjusted Z-score (Z) of eosinophils and aimed to evaluate the impact of onset age on eosinophils in KD patients. (2) Methods: We divided 398 KD patients into seven age subgroups. Laboratory data and the age-adjusted Z-score of eosinophils during the phases of Kawasaki disease were analyzed. (3) Results: The absolute eosinophil count among all age groups showed significant differences in the post-intravenous immunoglobulin (IVIG) phase and throughout the course of KD with Z-score adjusted for age. Further analysis showed persistent elevation of the age-adjusted Z-score of eosinophils (Z-eosinophil) especially in the under six-month-old age subgroup. In addition, we divided the Z-eosinophil into two groups to find the relationship with coronary artery lesions (CALs). Patients with a higher eosinophil count than average age values had a higher risk of developing CALs, while those with a lower eosinophil count than average age values had a lower risk of having CALs. (4) Conclusions: These findings may provide information to clinicians to pay attention to allergic diseases during the follow-up of KD, especially for children who are younger than 6 months old at the onset of KD, and eosinophil count could be a crucial focus in KD.https://www.mdpi.com/2227-9059/10/4/835ageeosinophilKawasaki diseaseZ-scorecoronary artery lesionallergy |
| spellingShingle | Yu-Jhen Chen Mindy Ming-Huey Guo Ling-Sai Chang Ho-Chang Kuo The Impact of Onset Age on Eosinophils in Kawasaki Disease Biomedicines age eosinophil Kawasaki disease Z-score coronary artery lesion allergy |
| title | The Impact of Onset Age on Eosinophils in Kawasaki Disease |
| title_full | The Impact of Onset Age on Eosinophils in Kawasaki Disease |
| title_fullStr | The Impact of Onset Age on Eosinophils in Kawasaki Disease |
| title_full_unstemmed | The Impact of Onset Age on Eosinophils in Kawasaki Disease |
| title_short | The Impact of Onset Age on Eosinophils in Kawasaki Disease |
| title_sort | impact of onset age on eosinophils in kawasaki disease |
| topic | age eosinophil Kawasaki disease Z-score coronary artery lesion allergy |
| url | https://www.mdpi.com/2227-9059/10/4/835 |
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