Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3984-3 |
| _version_ | 1828474210096250880 |
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| author | Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou |
| author_facet | Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou |
| author_sort | Voahangy Andrianaivoarimanana |
| collection | DOAJ |
| description | Abstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. Results Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. |
| first_indexed | 2024-12-11T05:57:21Z |
| format | Article |
| id | doaj.art-73e96147f7fb4765a28e07472f4a39fa |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T05:57:21Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-73e96147f7fb4765a28e07472f4a39fa2022-12-22T01:18:38ZengBMCBMC Research Notes1756-05002018-12-011111710.1186/s13104-018-3984-3Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in MadagascarVoahangy Andrianaivoarimanana0Minoarisoa Rajerison1Ronan Jambou2Unité Peste, Institut Pasteur de MadagascarUnité Peste, Institut Pasteur de MadagascarUnité d’Immunologie, Institut Pasteur de MadagascarAbstract Objectives In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. Results Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission.http://link.springer.com/article/10.1186/s13104-018-3984-3PlagueRattus rattusF1 antigenMadagascarOutbreak |
| spellingShingle | Voahangy Andrianaivoarimanana Minoarisoa Rajerison Ronan Jambou Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar BMC Research Notes Plague Rattus rattus F1 antigen Madagascar Outbreak |
| title | Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
| title_full | Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
| title_fullStr | Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
| title_full_unstemmed | Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
| title_short | Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar |
| title_sort | exposure to yersinia pestis increases resistance to plague in black rats and modulates transmission in madagascar |
| topic | Plague Rattus rattus F1 antigen Madagascar Outbreak |
| url | http://link.springer.com/article/10.1186/s13104-018-3984-3 |
| work_keys_str_mv | AT voahangyandrianaivoarimanana exposuretoyersiniapestisincreasesresistancetoplagueinblackratsandmodulatestransmissioninmadagascar AT minoarisoarajerison exposuretoyersiniapestisincreasesresistancetoplagueinblackratsandmodulatestransmissioninmadagascar AT ronanjambou exposuretoyersiniapestisincreasesresistancetoplagueinblackratsandmodulatestransmissioninmadagascar |