Sex disparities in the association between acute myocardial infarction and colon cancer risk
Abstract Background Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. Methods In thi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5205 |
| _version_ | 1797903102310875136 |
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| author | Shing‐Hsien Chou Chia‐Pin Lin Yu‐Sheng Lin Ting‐Hein Lee Chan‐Keng Yang Yu‐Sheng Lin Pao‐Hsien Chu |
| author_facet | Shing‐Hsien Chou Chia‐Pin Lin Yu‐Sheng Lin Ting‐Hein Lee Chan‐Keng Yang Yu‐Sheng Lin Pao‐Hsien Chu |
| author_sort | Shing‐Hsien Chou |
| collection | DOAJ |
| description | Abstract Background Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. Methods In this population‐based retrospective cohort study, 94,780 and 97,987 male patients and 38,697 and 72,007 female patients with and without new‐onset AMI, respectively, from January 1, 2001, to December 31, 2012, were enrolled from Taiwan's National Health Insurance Research Database. Inverse probability of treatment weighting (IPTW) was used to balance covariates across study groups. The primary outcome was a new diagnosis of colon cancer. Results The incidence rate of colon cancer was 1.54 (95% confidence interval [CI] = 1.46–1.62) and 1.40 (95% CI = 1.32–1.48) per 1000 person‐years in the male patients and 1.62 (95% CI = 1.50–1.74) and 1.22 (95% CI = 1.13–1.32) in the female patients, in the AMI and non‐AMI groups, respectively. AMI was associated with a significantly higher risk of colon cancer in the female patients (hazard ratio [HR] = 1.31, 95% CI = 1.06–1.61) but not in the male patients (HR = 1.09, 95% CI = 0.95–1.26). In the subgroup analysis, the association between AMI and colon cancer in the female patients was stronger in those aged ≥65 years (HR = 1.28, 95% CI = 1.13–1.44). Conclusions An increased risk of colon cancer was observed only in the female patients with AMI. The association between AMI and colon cancer in the female patients was the most evident in those aged ≥65 years. |
| first_indexed | 2024-04-10T09:27:40Z |
| format | Article |
| id | doaj.art-73e9a42d1e6546cfb74e4be84cb67cea |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:27:40Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-73e9a42d1e6546cfb74e4be84cb67cea2023-02-19T18:54:07ZengWileyCancer Medicine2045-76342023-02-011232958296910.1002/cam4.5205Sex disparities in the association between acute myocardial infarction and colon cancer riskShing‐Hsien Chou0Chia‐Pin Lin1Yu‐Sheng Lin2Ting‐Hein Lee3Chan‐Keng Yang4Yu‐Sheng Lin5Pao‐Hsien Chu6Division of Cardiology, Linko Branch Chang Gung Memorial Hospital Taoyuan TaiwanDivision of Cardiology, Linko Branch Chang Gung Memorial Hospital Taoyuan TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan TaiwanDivision of Cardiology, Linko Branch Chang Gung Memorial Hospital Taoyuan TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University Taoyuan TaiwanHealthcare center Chang Gung Memorial Hospital Taoyuan TaiwanDivision of Cardiology, Linko Branch Chang Gung Memorial Hospital Taoyuan TaiwanAbstract Background Acute myocardial infarction (AMI) and colon cancer share similar risk factors. Studies have suggested an association between AMI and colon cancer; however, evidence is conflicting. Whether sex disparities exist in this association in the real world remains unknown. Methods In this population‐based retrospective cohort study, 94,780 and 97,987 male patients and 38,697 and 72,007 female patients with and without new‐onset AMI, respectively, from January 1, 2001, to December 31, 2012, were enrolled from Taiwan's National Health Insurance Research Database. Inverse probability of treatment weighting (IPTW) was used to balance covariates across study groups. The primary outcome was a new diagnosis of colon cancer. Results The incidence rate of colon cancer was 1.54 (95% confidence interval [CI] = 1.46–1.62) and 1.40 (95% CI = 1.32–1.48) per 1000 person‐years in the male patients and 1.62 (95% CI = 1.50–1.74) and 1.22 (95% CI = 1.13–1.32) in the female patients, in the AMI and non‐AMI groups, respectively. AMI was associated with a significantly higher risk of colon cancer in the female patients (hazard ratio [HR] = 1.31, 95% CI = 1.06–1.61) but not in the male patients (HR = 1.09, 95% CI = 0.95–1.26). In the subgroup analysis, the association between AMI and colon cancer in the female patients was stronger in those aged ≥65 years (HR = 1.28, 95% CI = 1.13–1.44). Conclusions An increased risk of colon cancer was observed only in the female patients with AMI. The association between AMI and colon cancer in the female patients was the most evident in those aged ≥65 years.https://doi.org/10.1002/cam4.5205acute myocardial infarction (AMI)cardiovascular disease (CVD)colon cancerinverse probability of treatment weighting (IPTW)sex disparity |
| spellingShingle | Shing‐Hsien Chou Chia‐Pin Lin Yu‐Sheng Lin Ting‐Hein Lee Chan‐Keng Yang Yu‐Sheng Lin Pao‐Hsien Chu Sex disparities in the association between acute myocardial infarction and colon cancer risk Cancer Medicine acute myocardial infarction (AMI) cardiovascular disease (CVD) colon cancer inverse probability of treatment weighting (IPTW) sex disparity |
| title | Sex disparities in the association between acute myocardial infarction and colon cancer risk |
| title_full | Sex disparities in the association between acute myocardial infarction and colon cancer risk |
| title_fullStr | Sex disparities in the association between acute myocardial infarction and colon cancer risk |
| title_full_unstemmed | Sex disparities in the association between acute myocardial infarction and colon cancer risk |
| title_short | Sex disparities in the association between acute myocardial infarction and colon cancer risk |
| title_sort | sex disparities in the association between acute myocardial infarction and colon cancer risk |
| topic | acute myocardial infarction (AMI) cardiovascular disease (CVD) colon cancer inverse probability of treatment weighting (IPTW) sex disparity |
| url | https://doi.org/10.1002/cam4.5205 |
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