COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study
Pulmonary thrombosis (PT) is a frequent complication of COVID-19. However, the risk factors, predictive scores, and precise diagnostic guidelines on indications for CT pulmonary angiography (CTPA) are still lacking. This study aimed to analyze the clinical and laboratory characteristics associated w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7049 |
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| author | Loris Močibob Frano Šušak Maja Šitum Klaudija Višković Neven Papić Adriana Vince |
| author_facet | Loris Močibob Frano Šušak Maja Šitum Klaudija Višković Neven Papić Adriana Vince |
| author_sort | Loris Močibob |
| collection | DOAJ |
| description | Pulmonary thrombosis (PT) is a frequent complication of COVID-19. However, the risk factors, predictive scores, and precise diagnostic guidelines on indications for CT pulmonary angiography (CTPA) are still lacking. This study aimed to analyze the clinical and laboratory characteristics associated with PT in patients with COVID-19. We conducted a cohort study of consecutively hospitalized adult patients with COVID-19 who underwent CTPA at the University Hospital for Infectious Diseases in Zagreb, Croatia between 1 April and 31 December 2021. Of 2078 hospitalized patients, 575 (27.6%) underwent CTPA. PT was diagnosed in 178 (30.9%) patients (69.6% males, median age of 61, IQR 50–69 years). The PT group had a higher CRP, LDH, D-dimer, platelets, and CHOD score. PT was more frequent in patients requiring ≥15 L O<sub>2</sub>/min (25.0% vs. 39.7%). In multivariable analysis, only D-dimer ≥ 1.0 mg/L (OR 1.78, 95%CI 1.12–2.75) and O<sub>2</sub> ≥ 15 L (OR 1.89, 95%CI 1.26–2.84) were associated with PT. PT was not associated with in-hospital mortality. In conclusion, our data confirmed a high incidence of PT in hospitalized patients with COVID-19, however, no correlation with traditional risk factors and mortality was found. CTPA should be performed in patients requiring high-flow supplemental oxygen or those with increased D-dimer levels. |
| first_indexed | 2024-03-09T17:43:36Z |
| format | Article |
| id | doaj.art-73eb541da7134075a3f19024adc3ad49 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-73eb541da7134075a3f19024adc3ad492023-11-24T11:22:03ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123704910.3390/jcm11237049COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort StudyLoris Močibob0Frano Šušak1Maja Šitum2Klaudija Višković3Neven Papić4Adriana Vince5Department for Viral Hepatitis, University Hospital for Infectious Diseases Zagreb, Mirogojska 8, 10000 Zagreb, CroatiaDepartment of Infectious Diseases, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Infectious Diseases, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment for Radiology and Ultrasound Diagnostics, University Hospital for Infectious Diseases Zagreb, Mirogojska 8, 10000 Zagreb, CroatiaDepartment for Viral Hepatitis, University Hospital for Infectious Diseases Zagreb, Mirogojska 8, 10000 Zagreb, CroatiaDepartment for Viral Hepatitis, University Hospital for Infectious Diseases Zagreb, Mirogojska 8, 10000 Zagreb, CroatiaPulmonary thrombosis (PT) is a frequent complication of COVID-19. However, the risk factors, predictive scores, and precise diagnostic guidelines on indications for CT pulmonary angiography (CTPA) are still lacking. This study aimed to analyze the clinical and laboratory characteristics associated with PT in patients with COVID-19. We conducted a cohort study of consecutively hospitalized adult patients with COVID-19 who underwent CTPA at the University Hospital for Infectious Diseases in Zagreb, Croatia between 1 April and 31 December 2021. Of 2078 hospitalized patients, 575 (27.6%) underwent CTPA. PT was diagnosed in 178 (30.9%) patients (69.6% males, median age of 61, IQR 50–69 years). The PT group had a higher CRP, LDH, D-dimer, platelets, and CHOD score. PT was more frequent in patients requiring ≥15 L O<sub>2</sub>/min (25.0% vs. 39.7%). In multivariable analysis, only D-dimer ≥ 1.0 mg/L (OR 1.78, 95%CI 1.12–2.75) and O<sub>2</sub> ≥ 15 L (OR 1.89, 95%CI 1.26–2.84) were associated with PT. PT was not associated with in-hospital mortality. In conclusion, our data confirmed a high incidence of PT in hospitalized patients with COVID-19, however, no correlation with traditional risk factors and mortality was found. CTPA should be performed in patients requiring high-flow supplemental oxygen or those with increased D-dimer levels.https://www.mdpi.com/2077-0383/11/23/7049pulmonary thrombosisCOVID-19D-dimerpulmonary angiographyCTPAvenous thromboembolism |
| spellingShingle | Loris Močibob Frano Šušak Maja Šitum Klaudija Višković Neven Papić Adriana Vince COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study Journal of Clinical Medicine pulmonary thrombosis COVID-19 D-dimer pulmonary angiography CTPA venous thromboembolism |
| title | COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study |
| title_full | COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study |
| title_fullStr | COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study |
| title_full_unstemmed | COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study |
| title_short | COVID-19 and Pulmonary Thrombosis—An Unresolved Clinical Puzzle: A Single-Center Cohort Study |
| title_sort | covid 19 and pulmonary thrombosis an unresolved clinical puzzle a single center cohort study |
| topic | pulmonary thrombosis COVID-19 D-dimer pulmonary angiography CTPA venous thromboembolism |
| url | https://www.mdpi.com/2077-0383/11/23/7049 |
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