Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis
Background Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is characterised by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma, with advanced cases often complicated by progressive weight loss. Therefore, we hypothesised that nutritional status is associated with...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-05-01
|
| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/3/00749-2022.full |
| _version_ | 1797689347008364544 |
|---|---|
| author | Yuzo Suzuki Atsuki Fukada Kazutaka Mori Masato Kono Hirotsugu Hasegawa Dai Hashimoto Koshi Yokomura Shiro Imokawa Yusuke Inoue Hideki Yasui Hironao Hozumi Masato Karayama Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Naoki Inui Hidenori Nakamura Takafumi Suda |
| author_facet | Yuzo Suzuki Atsuki Fukada Kazutaka Mori Masato Kono Hirotsugu Hasegawa Dai Hashimoto Koshi Yokomura Shiro Imokawa Yusuke Inoue Hideki Yasui Hironao Hozumi Masato Karayama Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Naoki Inui Hidenori Nakamura Takafumi Suda |
| author_sort | Yuzo Suzuki |
| collection | DOAJ |
| description | Background
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is characterised by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma, with advanced cases often complicated by progressive weight loss. Therefore, we hypothesised that nutritional status is associated with mortality in IPPFE.
Methods
This retrospective study assesses nutritional status at the time of diagnosis and 1 year after diagnosis in 131 patients with IPPFE. Malnutrition-related risk was evaluated using the Geriatric Nutritional Risk Index (GNRI).
Results
Of the 131 patients, 96 (73.8%) were at malnutrition-related risk at the time of diagnosis according to the GNRI. Of these, 21 patients (16.0%) were classified as at major malnutrition-related risk (GNRI <82). Patients at major malnutrition-related risk were significantly older and had worse pulmonary function than patients at low (GNRI 92– <98) and moderate (GNRI 82– <92) malnutrition-related risk. GNRI scores decreased significantly from the time of diagnosis to 1 year after diagnosis. Patients with a lower GNRI (<91.8) had significantly shorter survival than patients with a median GNRI or higher (≥91.8). Patients with declines in annual GNRI scores of ≥5 had significantly shorter survival than patients with declines in annual GNRI scores of <5. In multivariate analysis, major malnutrition-related risk was significantly associated with increased mortality after adjustment for age, sex and forced vital capacity (hazard ratio 1.957). A composite scoring model including age, sex and major malnutrition-related risk was able to separate mortality risk in IPPFE.
Conclusion
Assessment of nutritional status by the GNRI provides useful information for managing patients with IPPFE by predicting mortality risk. |
| first_indexed | 2024-03-12T01:44:26Z |
| format | Article |
| id | doaj.art-73ec037f13204ed99b126dbcaadb79e3 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-12T01:44:26Z |
| publishDate | 2023-05-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-73ec037f13204ed99b126dbcaadb79e32023-09-09T13:53:53ZengEuropean Respiratory SocietyERJ Open Research2312-05412023-05-019310.1183/23120541.00749-202200749-2022Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosisYuzo Suzuki0Atsuki Fukada1Kazutaka Mori2Masato Kono3Hirotsugu Hasegawa4Dai Hashimoto5Koshi Yokomura6Shiro Imokawa7Yusuke Inoue8Hideki Yasui9Hironao Hozumi10Masato Karayama11Kazuki Furuhashi12Noriyuki Enomoto13Tomoyuki Fujisawa14Naoki Inui15Hidenori Nakamura16Takafumi Suda17 Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Department of Respiratory Medicine, Shizuoka City Shimizu Hospital, Shizuoka, Japan Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan Department of Respiratory Medicine, Seirei Mikatahara General Hospital, Hamamatsu, Japan Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan Department of Respiratory Medicine, Seirei Mikatahara General Hospital, Hamamatsu, Japan Department of Respiratory Medicine, Iwata City Hospital, Iwata, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Background Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is characterised by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma, with advanced cases often complicated by progressive weight loss. Therefore, we hypothesised that nutritional status is associated with mortality in IPPFE. Methods This retrospective study assesses nutritional status at the time of diagnosis and 1 year after diagnosis in 131 patients with IPPFE. Malnutrition-related risk was evaluated using the Geriatric Nutritional Risk Index (GNRI). Results Of the 131 patients, 96 (73.8%) were at malnutrition-related risk at the time of diagnosis according to the GNRI. Of these, 21 patients (16.0%) were classified as at major malnutrition-related risk (GNRI <82). Patients at major malnutrition-related risk were significantly older and had worse pulmonary function than patients at low (GNRI 92– <98) and moderate (GNRI 82– <92) malnutrition-related risk. GNRI scores decreased significantly from the time of diagnosis to 1 year after diagnosis. Patients with a lower GNRI (<91.8) had significantly shorter survival than patients with a median GNRI or higher (≥91.8). Patients with declines in annual GNRI scores of ≥5 had significantly shorter survival than patients with declines in annual GNRI scores of <5. In multivariate analysis, major malnutrition-related risk was significantly associated with increased mortality after adjustment for age, sex and forced vital capacity (hazard ratio 1.957). A composite scoring model including age, sex and major malnutrition-related risk was able to separate mortality risk in IPPFE. Conclusion Assessment of nutritional status by the GNRI provides useful information for managing patients with IPPFE by predicting mortality risk.http://openres.ersjournals.com/content/9/3/00749-2022.full |
| spellingShingle | Yuzo Suzuki Atsuki Fukada Kazutaka Mori Masato Kono Hirotsugu Hasegawa Dai Hashimoto Koshi Yokomura Shiro Imokawa Yusuke Inoue Hideki Yasui Hironao Hozumi Masato Karayama Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Naoki Inui Hidenori Nakamura Takafumi Suda Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis ERJ Open Research |
| title | Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| title_full | Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| title_fullStr | Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| title_full_unstemmed | Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| title_short | Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| title_sort | assessment of malnutrition related risk in patients with idiopathic pleuroparenchymal fibroelastosis |
| url | http://openres.ersjournals.com/content/9/3/00749-2022.full |
| work_keys_str_mv | AT yuzosuzuki assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT atsukifukada assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT kazutakamori assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT masatokono assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT hirotsuguhasegawa assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT daihashimoto assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT koshiyokomura assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT shiroimokawa assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT yusukeinoue assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT hidekiyasui assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT hironaohozumi assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT masatokarayama assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT kazukifuruhashi assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT noriyukienomoto assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT tomoyukifujisawa assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT naokiinui assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT hidenorinakamura assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis AT takafumisuda assessmentofmalnutritionrelatedriskinpatientswithidiopathicpleuroparenchymalfibroelastosis |