Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress

Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress

Human amylin or islet amyloid polypeptide (hIAPP) is synthesized in the pancreatic β-cells and has been shown to contribute to the pathogenesis of type 2 diabetes (T2D) in vitro and in vivo. This study compared amylin oligomerization/expression and signal transduction under endoplasmic reticulum (ER...

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Bibliographic Details
Main Authors: Yeong-Min Yoo, Seong Soo Joo
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
human amylin or islet amyloid polypeptide
overexpression
ER stress
oxidative stress
INS-1E cells
Online Access:https://www.mdpi.com/1422-0067/22/21/11341

Internet

https://www.mdpi.com/1422-0067/22/21/11341

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