RNF125 is a Ubiquitin-Protein Ligase that Promotes p53 Degradation

RNF125 is a Ubiquitin-Protein Ligase that Promotes p53 Degradation

Background/Aims: Although early studies show that Mdm2 is the primary E3 ubiquitin ligase for the p53 tumor suppressor, an increasing amount of data suggests that p53 ubiquitination and degradation are more complex than once thought. Here, we investigated the role of RNF125, a non-Mdm2 ubiquitin-pro...

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Bibliographic Details
Main Authors: Liuzhong Yang, Bing Zhou, Xiaorui Li, Zhihong Lu, Weiwei Li, Xiaoqing Huo, Zhanhui Miao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
RNF125
p53
E3 ubiquitin ligase
Proteasome degradation
Online Access:http://www.karger.com/Article/FullText/369691

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