Using choroidal thickness to detect myopic macular degeneration
AIM: To explore the usage of choroidal thickness measured by swept-source optical coherence tomography (SS-OCT) to detect myopic macular degeneration (MMD) in high myopic participants. METHODS: Participants with bilateral high myopia (≤−6 diopters) were recruited from a subset of the Guangzhou Zhong...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2024/2/20240214.pdf |
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| author | Ran Liu Meng Xuan De-Cai Wang Ou Xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui Qiu-Xia Yin Ming-Guang He Zhi-Xi Li |
| author_facet | Ran Liu Meng Xuan De-Cai Wang Ou Xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui Qiu-Xia Yin Ming-Guang He Zhi-Xi Li |
| author_sort | Ran Liu |
| collection | DOAJ |
| description | AIM: To explore the usage of choroidal thickness measured by swept-source optical coherence tomography (SS-OCT) to detect myopic macular degeneration (MMD) in high myopic participants. METHODS: Participants with bilateral high myopia (≤−6 diopters) were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study. SS-OCT was performed to determine the choroidal thickness, and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia (META-PM) Classi?cation. Presence of MMD was defined as META-PM category 2 or above. RESULTS: A total of 568 right eyes were included for analysis. Eyes with MMD (n=106, 18.7%) were found to have older age, longer axial lengths (AL), higher myopic spherical equivalents (SE), and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector (P<0.001). The area under the receiver operating characteristic (ROC) curves (AUC) for subfoveal choroidal thickness (0.907) was greater than that of the model, including age, AL, and SE at 0.6249, 0.8208, and 0.8205, respectively. The choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD (AUC of 0.928 and 0.923, respectively). An outer nasal sector choroidal thickness of less than 74 µm demonstrated the highest odds of predicting MMD (OR=33.8). CONCLUSION: Choroidal thickness detects the presence of MMD with high agreement, particularly of the inner and outer nasal sectors of the posterior pole, which appears to be a biometric parameter more precise than age, AL, or SE. |
| first_indexed | 2024-03-08T12:08:44Z |
| format | Article |
| id | doaj.art-73efb8a9acf94022bb116dcf5684149d |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-08T12:08:44Z |
| publishDate | 2024-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-73efb8a9acf94022bb116dcf5684149d2024-01-23T03:42:33ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982024-02-0117231732310.18240/ijo.2024.02.1420240214Using choroidal thickness to detect myopic macular degenerationRan Liu0Meng Xuan1De-Cai Wang2Ou Xiao3Xin-Xing Guo4Jian Zhang5Wei Wang6Monica Jong7Padmaja Sankaridurg8Kyoko Ohno-Matsui9Qiu-Xia Yin10Ming-Guang He11Zhi-Xi Li12Ming-Guang He. School of Optometry, the Hong Kong Polytechnic University, Hong Kong SAR, China. mingguang.he@polyu.edu.hk; Zhi-Xi Li. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, China. lzx11-11@163.comState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaWilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21231, USAState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaBrien Holden Vision Institute, Sydney 2052, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney 2052, AustraliaBrien Holden Vision Institute, Sydney 2052, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney 2052, AustraliaDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 113-8510, JapanState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, China; School of Optometry, the Hong Kong Polytechnic University, Hong Kong SAR, China; Research Centre for SHARP Vision, the Hong Kong Polytechnic University, Hong Kong SAR, China; Center for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong SAR, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, ChinaAIM: To explore the usage of choroidal thickness measured by swept-source optical coherence tomography (SS-OCT) to detect myopic macular degeneration (MMD) in high myopic participants. METHODS: Participants with bilateral high myopia (≤−6 diopters) were recruited from a subset of the Guangzhou Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study. SS-OCT was performed to determine the choroidal thickness, and myopic maculopathy was graded by the International Meta-Analysis for Pathologic Myopia (META-PM) Classi?cation. Presence of MMD was defined as META-PM category 2 or above. RESULTS: A total of 568 right eyes were included for analysis. Eyes with MMD (n=106, 18.7%) were found to have older age, longer axial lengths (AL), higher myopic spherical equivalents (SE), and reduced choroidal thickness in each Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector (P<0.001). The area under the receiver operating characteristic (ROC) curves (AUC) for subfoveal choroidal thickness (0.907) was greater than that of the model, including age, AL, and SE at 0.6249, 0.8208, and 0.8205, respectively. The choroidal thickness of the inner and outer nasal sectors was the most accurate indicator of MMD (AUC of 0.928 and 0.923, respectively). An outer nasal sector choroidal thickness of less than 74 µm demonstrated the highest odds of predicting MMD (OR=33.8). CONCLUSION: Choroidal thickness detects the presence of MMD with high agreement, particularly of the inner and outer nasal sectors of the posterior pole, which appears to be a biometric parameter more precise than age, AL, or SE.http://ies.ijo.cn/en_publish/2024/2/20240214.pdfhigh myopiachoroidal thicknessmyopic macular degenerationswept-source optical coherence tomography |
| spellingShingle | Ran Liu Meng Xuan De-Cai Wang Ou Xiao Xin-Xing Guo Jian Zhang Wei Wang Monica Jong Padmaja Sankaridurg Kyoko Ohno-Matsui Qiu-Xia Yin Ming-Guang He Zhi-Xi Li Using choroidal thickness to detect myopic macular degeneration International Journal of Ophthalmology high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography |
| title | Using choroidal thickness to detect myopic macular degeneration |
| title_full | Using choroidal thickness to detect myopic macular degeneration |
| title_fullStr | Using choroidal thickness to detect myopic macular degeneration |
| title_full_unstemmed | Using choroidal thickness to detect myopic macular degeneration |
| title_short | Using choroidal thickness to detect myopic macular degeneration |
| title_sort | using choroidal thickness to detect myopic macular degeneration |
| topic | high myopia choroidal thickness myopic macular degeneration swept-source optical coherence tomography |
| url | http://ies.ijo.cn/en_publish/2024/2/20240214.pdf |
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