Inter and intradevice assessment of microperimetry testing in aging eyes
Abstract Microperimetry (MP) is a psychometric examination combining retinal imaging and functional sensitivity testing with an increasing importance due to its potential use as clinical study outcome. We investigated the repeatability of pointwise retinal sensitivity (PWS) on the most advanced comm...
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| פורמט: | Article |
| שפה: | English |
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Nature Portfolio
2024-01-01
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| סדרה: | Scientific Reports |
| גישה מקוונת: | https://doi.org/10.1038/s41598-024-51539-0 |
| _version_ | 1827382202389757952 |
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| author | Leonard M. Coulibaly Hamza Mohamed Philipp Fuchs Ursula Schmidt-Erfurth Gregor S. Reiter |
| author_facet | Leonard M. Coulibaly Hamza Mohamed Philipp Fuchs Ursula Schmidt-Erfurth Gregor S. Reiter |
| author_sort | Leonard M. Coulibaly |
| collection | DOAJ |
| description | Abstract Microperimetry (MP) is a psychometric examination combining retinal imaging and functional sensitivity testing with an increasing importance due to its potential use as clinical study outcome. We investigated the repeatability of pointwise retinal sensitivity (PWS) on the most advanced commercially available MP devices under their standard setting in a healthy aging population. Two successive MP examinations on both MP-3 (NIDEK CO., Ltd., Gamagori, Japan) and MAIA (CenterVue S.p.A. (iCare), Padova, Italy) were performed on healthy aging subjects in a randomized order. PWS repeatability was analysed for different macular regions and age groups using Bland-Altmann coefficients of repeatability (CoR). A total of 3600 stimuli from 20 healthy individuals with a mean age of 70 (11) years were included. Mean CoR in dB were ±4.61 for MAIA and ±4.55 for MP-3 examinations. A lower repeatability (p=0.005) was detected in the central millimetre on MAIA examinations. Higher subject age was associated with a lower repeatability of PWS on both devices (both p=0.003). Intra-device correlation was good (MAIA: 0.79 [0.76–0.81]; MP-3: 0.72 [0.68–0.76]) whereas a moderate mean inter-device correlation (0.6 [0.55–0.65]) could be detected. In conclusion, older subjects and the foveal region are associated with a worse pointwise repeatability. |
| first_indexed | 2024-03-08T14:16:09Z |
| format | Article |
| id | doaj.art-73f0e9475846450ba9b3ad4165d0bca3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T14:16:09Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-73f0e9475846450ba9b3ad4165d0bca32024-01-14T12:22:06ZengNature PortfolioScientific Reports2045-23222024-01-011411910.1038/s41598-024-51539-0Inter and intradevice assessment of microperimetry testing in aging eyesLeonard M. Coulibaly0Hamza Mohamed1Philipp Fuchs2Ursula Schmidt-Erfurth3Gregor S. Reiter4Department of Ophthalmology and Optometry, Vienna Clinical Trial Centre (VTC), Medical University of ViennaLaboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of ViennaDepartment of Ophthalmology and Optometry, Vienna Clinical Trial Centre (VTC), Medical University of ViennaDepartment of Ophthalmology and Optometry, Vienna Clinical Trial Centre (VTC), Medical University of ViennaLaboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of ViennaAbstract Microperimetry (MP) is a psychometric examination combining retinal imaging and functional sensitivity testing with an increasing importance due to its potential use as clinical study outcome. We investigated the repeatability of pointwise retinal sensitivity (PWS) on the most advanced commercially available MP devices under their standard setting in a healthy aging population. Two successive MP examinations on both MP-3 (NIDEK CO., Ltd., Gamagori, Japan) and MAIA (CenterVue S.p.A. (iCare), Padova, Italy) were performed on healthy aging subjects in a randomized order. PWS repeatability was analysed for different macular regions and age groups using Bland-Altmann coefficients of repeatability (CoR). A total of 3600 stimuli from 20 healthy individuals with a mean age of 70 (11) years were included. Mean CoR in dB were ±4.61 for MAIA and ±4.55 for MP-3 examinations. A lower repeatability (p=0.005) was detected in the central millimetre on MAIA examinations. Higher subject age was associated with a lower repeatability of PWS on both devices (both p=0.003). Intra-device correlation was good (MAIA: 0.79 [0.76–0.81]; MP-3: 0.72 [0.68–0.76]) whereas a moderate mean inter-device correlation (0.6 [0.55–0.65]) could be detected. In conclusion, older subjects and the foveal region are associated with a worse pointwise repeatability.https://doi.org/10.1038/s41598-024-51539-0 |
| spellingShingle | Leonard M. Coulibaly Hamza Mohamed Philipp Fuchs Ursula Schmidt-Erfurth Gregor S. Reiter Inter and intradevice assessment of microperimetry testing in aging eyes Scientific Reports |
| title | Inter and intradevice assessment of microperimetry testing in aging eyes |
| title_full | Inter and intradevice assessment of microperimetry testing in aging eyes |
| title_fullStr | Inter and intradevice assessment of microperimetry testing in aging eyes |
| title_full_unstemmed | Inter and intradevice assessment of microperimetry testing in aging eyes |
| title_short | Inter and intradevice assessment of microperimetry testing in aging eyes |
| title_sort | inter and intradevice assessment of microperimetry testing in aging eyes |
| url | https://doi.org/10.1038/s41598-024-51539-0 |
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