PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies
Abstract Background Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs...
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| Format: | Article |
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BMC
2024-02-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-024-01205-9 |
| _version_ | 1797273106677497856 |
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| author | Peiyu Liu Dandan Sun Shuchang Zhang Shimei Chen Xiaoqian Wang Huiming Li Fang Wei |
| author_facet | Peiyu Liu Dandan Sun Shuchang Zhang Shimei Chen Xiaoqian Wang Huiming Li Fang Wei |
| author_sort | Peiyu Liu |
| collection | DOAJ |
| description | Abstract Background Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor (VEGF) targets the core pathology of ocular angiogenesis. Main body In recent years, therapies targeting metabolism to prevent angiogenesis have also rapidly developed, offering assistance to patients with a poor prognosis while receiving anti-VEGF therapy and reducing the side effects associated with long-term VEGF usage. Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a key enzyme in targeted metabolism, has been shown to have great potential, with antiangiogenic effects and multiple protective effects in the treatment of neovascular eye disease. In this review, we summarize the mechanisms of common types of neovascular eye diseases; discuss the protective effect and potential mechanism of targeting PFKFB3, including the related inhibitors of PFKFB3; and look forward to the future exploration directions and therapeutic prospects of PFKFB3 in neovascular eye disease. Conclusion Neovascular eye disease, the most common and severely debilitating retinal disease, is largely incurable, necessitating the exploration of new treatment methods. PFKFB3 has been shown to possess various potential protective mechanisms in treating neovascular eye disease. With the development of several drugs targeting PFKFB3 and their gradual entry into clinical research, targeting PFKFB3-mediated glycolysis has emerged as a promising therapeutic approach for the future of neovascular eye disease. |
| first_indexed | 2024-03-07T14:38:51Z |
| format | Article |
| id | doaj.art-73f4401577674bf28b4c37085a48c8a8 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-03-07T14:38:51Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-73f4401577674bf28b4c37085a48c8a82024-03-05T20:28:58ZengBMCCell & Bioscience2045-37012024-02-0114111610.1186/s13578-024-01205-9PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategiesPeiyu Liu0Dandan Sun1Shuchang Zhang2Shimei Chen3Xiaoqian Wang4Huiming Li5Fang Wei6Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineShanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor (VEGF) targets the core pathology of ocular angiogenesis. Main body In recent years, therapies targeting metabolism to prevent angiogenesis have also rapidly developed, offering assistance to patients with a poor prognosis while receiving anti-VEGF therapy and reducing the side effects associated with long-term VEGF usage. Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a key enzyme in targeted metabolism, has been shown to have great potential, with antiangiogenic effects and multiple protective effects in the treatment of neovascular eye disease. In this review, we summarize the mechanisms of common types of neovascular eye diseases; discuss the protective effect and potential mechanism of targeting PFKFB3, including the related inhibitors of PFKFB3; and look forward to the future exploration directions and therapeutic prospects of PFKFB3 in neovascular eye disease. Conclusion Neovascular eye disease, the most common and severely debilitating retinal disease, is largely incurable, necessitating the exploration of new treatment methods. PFKFB3 has been shown to possess various potential protective mechanisms in treating neovascular eye disease. With the development of several drugs targeting PFKFB3 and their gradual entry into clinical research, targeting PFKFB3-mediated glycolysis has emerged as a promising therapeutic approach for the future of neovascular eye disease.https://doi.org/10.1186/s13578-024-01205-9PFKFB3Ocular angiogenesisGlycolysisEndothelial cellsOxidative stress |
| spellingShingle | Peiyu Liu Dandan Sun Shuchang Zhang Shimei Chen Xiaoqian Wang Huiming Li Fang Wei PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies Cell & Bioscience PFKFB3 Ocular angiogenesis Glycolysis Endothelial cells Oxidative stress |
| title | PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies |
| title_full | PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies |
| title_fullStr | PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies |
| title_full_unstemmed | PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies |
| title_short | PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies |
| title_sort | pfkfb3 in neovascular eye disease unraveling mechanisms and exploring therapeutic strategies |
| topic | PFKFB3 Ocular angiogenesis Glycolysis Endothelial cells Oxidative stress |
| url | https://doi.org/10.1186/s13578-024-01205-9 |
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