Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors
155 children and adolescents who had been diagnosed oncohematological diseases and had undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors of bacterial infections were acute...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/150 |
| _version_ | 1797702634835017728 |
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| author | M. Yu. Averyanova V. N. Vavilov S. N. Bondarenko O. S. Uspenskaya N. V. Stancheva E. V. Semenova A. G. Volkova B. I. Smirnov I. B. Baranova L. S. Zubarovskaya N. N. Klimko B. V. Afanasyev |
| author_facet | M. Yu. Averyanova V. N. Vavilov S. N. Bondarenko O. S. Uspenskaya N. V. Stancheva E. V. Semenova A. G. Volkova B. I. Smirnov I. B. Baranova L. S. Zubarovskaya N. N. Klimko B. V. Afanasyev |
| author_sort | M. Yu. Averyanova |
| collection | DOAJ |
| description | 155 children and adolescents who had been diagnosed oncohematological diseases and had undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors of bacterial infections were acute leukemia (73%), acute «graft versus host disease» (61%), severe infectious complications before HSCT (30%), cytomegaloviral reactivation (51%). Main causative agents were Kl. pneumoniae (15%), Escherichia coli (8%), Enterobacter sp. (7%), Pseudomonas sp. (6,5%), Enterococcus sp. (16,5%), S.еpidermidis (13,5%). Most frequent involved sites are urinary tract (30,6%), lungs (22,5%) and bacteriemia (38,7%). Rise in ciprofloxacin resistans among Entorobactri, aerobic and Gram-positive cocci. General survival rate of patients with bacterial complications was 36,3% (p<0,001). Number of infectious episodes and their severity were statistically significant (both p<0,001) deteriorating factor for general surviral rate. |
| first_indexed | 2024-03-12T04:52:55Z |
| format | Article |
| id | doaj.art-73f4b9e92715452981d23c7058bfabef |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:52:55Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-73f4b9e92715452981d23c7058bfabef2023-09-03T09:18:10ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0151354310.22625/2072-6732-2013-5-1-35-43164Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factorsM. Yu. Averyanova0V. N. Vavilov1S. N. Bondarenko2O. S. Uspenskaya3N. V. Stancheva4E. V. Semenova5A. G. Volkova6B. I. Smirnov7I. B. Baranova8L. S. Zubarovskaya9N. N. Klimko10B. V. Afanasyev11Институт детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургСанкт-Петербургский государственный электротехнический университет им. В.И. Ульянова, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-ПетербургСеверо-Западный государственный медицинский университет им. И.И. Мечникова, Санкт-ПетербургИнститут детской гематологии и трансплантологии им. Р.М. Горбачевой Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова, Санкт-Петербург155 children and adolescents who had been diagnosed oncohematological diseases and had undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors of bacterial infections were acute leukemia (73%), acute «graft versus host disease» (61%), severe infectious complications before HSCT (30%), cytomegaloviral reactivation (51%). Main causative agents were Kl. pneumoniae (15%), Escherichia coli (8%), Enterobacter sp. (7%), Pseudomonas sp. (6,5%), Enterococcus sp. (16,5%), S.еpidermidis (13,5%). Most frequent involved sites are urinary tract (30,6%), lungs (22,5%) and bacteriemia (38,7%). Rise in ciprofloxacin resistans among Entorobactri, aerobic and Gram-positive cocci. General survival rate of patients with bacterial complications was 36,3% (p<0,001). Number of infectious episodes and their severity were statistically significant (both p<0,001) deteriorating factor for general surviral rate.https://journal.niidi.ru/jofin/article/view/150трансплантация аллогенных гемопоэтических стволовых клетокбактериальные инфекциифакторы риска. |
| spellingShingle | M. Yu. Averyanova V. N. Vavilov S. N. Bondarenko O. S. Uspenskaya N. V. Stancheva E. V. Semenova A. G. Volkova B. I. Smirnov I. B. Baranova L. S. Zubarovskaya N. N. Klimko B. V. Afanasyev Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors Журнал инфектологии трансплантация аллогенных гемопоэтических стволовых клеток бактериальные инфекции факторы риска. |
| title | Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors |
| title_full | Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors |
| title_fullStr | Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors |
| title_full_unstemmed | Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors |
| title_short | Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors |
| title_sort | bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients etiology structure risk factors |
| topic | трансплантация аллогенных гемопоэтических стволовых клеток бактериальные инфекции факторы риска. |
| url | https://journal.niidi.ru/jofin/article/view/150 |
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