Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line
Background and Aims: Oral squamous cell carcinoma (OSCC) is one of the most prevalent oral cancers with increased risk in individuals younger than 40 years especially in developed countries. There are many evidences that people who have plenty of fruits and vegetables in their diets tend to have low...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2020-04-01
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| Series: | Journal of Dental Medicine |
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| Online Access: | http://jdm.tums.ac.ir/article-1-5949-en.html |
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| author | Ali Dehghani Nazhvani Mahboobeh Razmkhah Amirreza Jassbi Mohammadreza Khademalizadeh Afsoon Mahmoodi |
| author_facet | Ali Dehghani Nazhvani Mahboobeh Razmkhah Amirreza Jassbi Mohammadreza Khademalizadeh Afsoon Mahmoodi |
| author_sort | Ali Dehghani Nazhvani |
| collection | DOAJ |
| description | Background and Aims: Oral squamous cell carcinoma (OSCC) is one of the most prevalent oral cancers with increased risk in individuals younger than 40 years especially in developed countries. There are many evidences that people who have plenty of fruits and vegetables in their diets tend to have lower risk of cancer. In this study, we evaluated the anticancer effect of four medicinal plants of Otostegia Persica, Otostegia Michauxii, Otostegia Aucheri, and Hibiscus Sabdariffa on OSCC cell lines.
Materials and Methods: In this study, methanolic & dichloromethane extracts of the above medicinal plants were used in order to evaluate their effect on oral squamous cell carcinoma cell line in different concentrations and after 24 , 48 and 72 hrs by MTT assay test. Finally, the appropriate concentration for repeating the test were chosen.
Results: In this study, the mean amounts of IC50 for O. persica and O. Aucheri were less than the two other herbs and the least and most amount of IC50 were related to the dicloromethanolic extract of O. persica after 72 hrs and the water extract of H. sabdariffa after 24 hrs, respectively.
Conclusion: It was concluded that all of the plants evaluated especially O.Persica and O.Aucheri had anticancer properties and dichloromethalonic extracts of these plant were more effective than that of methanolic extract. |
| first_indexed | 2024-12-11T23:52:21Z |
| format | Article |
| id | doaj.art-73f6394812164228ade319fb657fcc87 |
| institution | Directory Open Access Journal |
| issn | 1024-641X 2008-2444 |
| language | fas |
| last_indexed | 2024-12-11T23:52:21Z |
| publishDate | 2020-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Medicine |
| spelling | doaj.art-73f6394812164228ade319fb657fcc872022-12-22T00:45:26ZfasTehran University of Medical SciencesJournal of Dental Medicine1024-641X2008-24442020-04-01324208215Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell lineAli Dehghani Nazhvani0Mahboobeh Razmkhah1Amirreza Jassbi2Mohammadreza Khademalizadeh3Afsoon Mahmoodi4 Assistant Professor, Department of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Assistant Professor, Department of Immunology, School of Medicine Shiraz University of Medical Sciences, School of Dentistry, Shiraz, Iran; Member of Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, Iran Associate Professor, Department of Phytochemistry, Faculty of Pharmacy, Shiraz University of Medical Science; Member of Medicinal and Natural Products Reasearch Center, Shiraz University of Medical Sciences, Shiraz, Iran Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Student research committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Background and Aims: Oral squamous cell carcinoma (OSCC) is one of the most prevalent oral cancers with increased risk in individuals younger than 40 years especially in developed countries. There are many evidences that people who have plenty of fruits and vegetables in their diets tend to have lower risk of cancer. In this study, we evaluated the anticancer effect of four medicinal plants of Otostegia Persica, Otostegia Michauxii, Otostegia Aucheri, and Hibiscus Sabdariffa on OSCC cell lines. Materials and Methods: In this study, methanolic & dichloromethane extracts of the above medicinal plants were used in order to evaluate their effect on oral squamous cell carcinoma cell line in different concentrations and after 24 , 48 and 72 hrs by MTT assay test. Finally, the appropriate concentration for repeating the test were chosen. Results: In this study, the mean amounts of IC50 for O. persica and O. Aucheri were less than the two other herbs and the least and most amount of IC50 were related to the dicloromethanolic extract of O. persica after 72 hrs and the water extract of H. sabdariffa after 24 hrs, respectively. Conclusion: It was concluded that all of the plants evaluated especially O.Persica and O.Aucheri had anticancer properties and dichloromethalonic extracts of these plant were more effective than that of methanolic extract.http://jdm.tums.ac.ir/article-1-5949-en.htmlotostegia aucherihibiscus sabdariffamttanticancer effect |
| spellingShingle | Ali Dehghani Nazhvani Mahboobeh Razmkhah Amirreza Jassbi Mohammadreza Khademalizadeh Afsoon Mahmoodi Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line Journal of Dental Medicine otostegia aucheri hibiscus sabdariffa mtt anticancer effect |
| title | Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line |
| title_full | Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line |
| title_fullStr | Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line |
| title_full_unstemmed | Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line |
| title_short | Evaluation of anticancer effect of Hibiscus Sabdarifa, Otostegia Persica Otostegia Aucheri, and Otostegia Michauxii on oral squamous cell carcinoma cell line |
| title_sort | evaluation of anticancer effect of hibiscus sabdarifa otostegia persica otostegia aucheri and otostegia michauxii on oral squamous cell carcinoma cell line |
| topic | otostegia aucheri hibiscus sabdariffa mtt anticancer effect |
| url | http://jdm.tums.ac.ir/article-1-5949-en.html |
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