Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants
Background: The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.Methods: Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal ac...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2013-03-01
|
| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | http://ijpa.tums.ac.ir/index.php/ijpa/article/view/573/391 |
| _version_ | 1823925257760669696 |
|---|---|
| author | JF Sanchez-Suarez I Riveros G Delgado |
| author_facet | JF Sanchez-Suarez I Riveros G Delgado |
| author_sort | JF Sanchez-Suarez |
| collection | DOAJ |
| description | Background: The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.Methods: Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of Leishmania associated with cutaneous leishmaniasis. Results: Seven essential oils exhibited activity against Leishmania parasites, five of which were toxic against J774 macrophages. Selectivity indices of >6 and 13 were calculated for the essential oils of Ocimum basilicum and Origanum vulgare, respectively.Conclusion: The essential oil of Ocimum basilicum was active against promastigotes of Leishmania and innocuous to J774 macrophages at concentrations up to 1600 µg/mL and should be further investigated for leishmanicidal activity in others in vitro and in vivo experimental models. |
| first_indexed | 2024-12-16T20:05:55Z |
| format | Article |
| id | doaj.art-73f67096a7af4c1fa432634714ef98c6 |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-12-16T20:05:55Z |
| publishDate | 2013-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-73f67096a7af4c1fa432634714ef98c62022-12-21T22:18:18ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2013-03-0181129136Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian PlantsJF Sanchez-SuarezI RiverosG DelgadoBackground: The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.Methods: Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of Leishmania associated with cutaneous leishmaniasis. Results: Seven essential oils exhibited activity against Leishmania parasites, five of which were toxic against J774 macrophages. Selectivity indices of >6 and 13 were calculated for the essential oils of Ocimum basilicum and Origanum vulgare, respectively.Conclusion: The essential oil of Ocimum basilicum was active against promastigotes of Leishmania and innocuous to J774 macrophages at concentrations up to 1600 µg/mL and should be further investigated for leishmanicidal activity in others in vitro and in vivo experimental models.http://ijpa.tums.ac.ir/index.php/ijpa/article/view/573/391Essential OilsAntileishmanial PropertiesLeishmaniaPlantColombia |
| spellingShingle | JF Sanchez-Suarez I Riveros G Delgado Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants Iranian Journal of Parasitology Essential Oils Antileishmanial Properties Leishmania Plant Colombia |
| title | Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants |
| title_full | Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants |
| title_fullStr | Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants |
| title_full_unstemmed | Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants |
| title_short | Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived from Ten Colombian Plants |
| title_sort | evaluation of the leishmanicidal and cytotoxic potential of essential oils derived from ten colombian plants |
| topic | Essential Oils Antileishmanial Properties Leishmania Plant Colombia |
| url | http://ijpa.tums.ac.ir/index.php/ijpa/article/view/573/391 |
| work_keys_str_mv | AT jfsanchezsuarez evaluationoftheleishmanicidalandcytotoxicpotentialofessentialoilsderivedfromtencolombianplants AT iriveros evaluationoftheleishmanicidalandcytotoxicpotentialofessentialoilsderivedfromtencolombianplants AT gdelgado evaluationoftheleishmanicidalandcytotoxicpotentialofessentialoilsderivedfromtencolombianplants |