Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.

Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.

Mice in which Cbl is unable to bind PI3K (YF mice) display increased bone volume due to enhanced bone formation and repressed bone resorption during normal bone homeostasis. We investigated the effects of disrupted Cbl-PI3K interaction on fracture healing to determine whether this interaction has an...

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Bibliographic Details
Main Authors: Vanessa Scanlon, Do Yu Soung, Naga Suresh Adapala, Elise Morgan, Marc F Hansen, Hicham Drissi, Archana Sanjay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4578922?pdf=render

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