Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

Abstract Background Alzheimer’s disease (AD) is the most well-known and most common type of age-related dementia. Amyloid deposition and hyperphosphorylation of tau protein are both pathological hallmarks of AD. Using a triple-transgenic mouse model (3xTg-AD) that develops plaques and tangles in the...

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Bibliographic Details
Main Authors: Roger N. Rosenberg, Min Fu, Doris Lambracht-Washington
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Immunotherapy
DNA vaccination
Amyloid-β
Aβ oligomer
Tau
Online Access:http://link.springer.com/article/10.1186/s13195-018-0441-4

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