Role of MOB4 in Cell Proliferation and Neurogenesis
Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Her...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | BioChem |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-6411/3/4/13 |
| _version_ | 1797382042056392704 |
|---|---|
| author | Inês B. Santos Juan Garrido-Maraver Carolina Gonçalves Bruna I. Oliveira Álvaro A. Tavares |
| author_facet | Inês B. Santos Juan Garrido-Maraver Carolina Gonçalves Bruna I. Oliveira Álvaro A. Tavares |
| author_sort | Inês B. Santos |
| collection | DOAJ |
| description | Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals. |
| first_indexed | 2024-03-08T20:59:46Z |
| format | Article |
| id | doaj.art-73fa8b707ccc43f4949f44c8855521da |
| institution | Directory Open Access Journal |
| issn | 2673-6411 |
| language | English |
| last_indexed | 2024-03-08T20:59:46Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioChem |
| spelling | doaj.art-73fa8b707ccc43f4949f44c8855521da2023-12-22T13:53:56ZengMDPI AGBioChem2673-64112023-12-013418219610.3390/biochem3040013Role of MOB4 in Cell Proliferation and NeurogenesisInês B. Santos0Juan Garrido-Maraver1Carolina Gonçalves2Bruna I. Oliveira3Álvaro A. Tavares4Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, PortugalFaculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, PortugalFaculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, PortugalFaculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, PortugalFaculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, PortugalSignaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that plays a diversity of roles in cell proliferation, sperm cell differentiation and is simultaneously involved in synapse formation and neural development. In addition, the gene is often overexpressed in a large diversity of tumors and is linked to poor clinical outcomes. Nevertheless, Mob4 molecular functions remain poorly defined, although it integrates the core structure of STRIPAK, a kinase/phosphatase protein complex, that can act upstream of the Hippo pathway. In this review we focus on the recent findings of Mob4 functions, that have begun to clarify its critical role on cell proliferation and the development of tissues and individuals.https://www.mdpi.com/2673-6411/3/4/13cell proliferationneurogenesisspermatogenesishippo pathwaySTRIPAKMob4 |
| spellingShingle | Inês B. Santos Juan Garrido-Maraver Carolina Gonçalves Bruna I. Oliveira Álvaro A. Tavares Role of MOB4 in Cell Proliferation and Neurogenesis BioChem cell proliferation neurogenesis spermatogenesis hippo pathway STRIPAK Mob4 |
| title | Role of MOB4 in Cell Proliferation and Neurogenesis |
| title_full | Role of MOB4 in Cell Proliferation and Neurogenesis |
| title_fullStr | Role of MOB4 in Cell Proliferation and Neurogenesis |
| title_full_unstemmed | Role of MOB4 in Cell Proliferation and Neurogenesis |
| title_short | Role of MOB4 in Cell Proliferation and Neurogenesis |
| title_sort | role of mob4 in cell proliferation and neurogenesis |
| topic | cell proliferation neurogenesis spermatogenesis hippo pathway STRIPAK Mob4 |
| url | https://www.mdpi.com/2673-6411/3/4/13 |
| work_keys_str_mv | AT inesbsantos roleofmob4incellproliferationandneurogenesis AT juangarridomaraver roleofmob4incellproliferationandneurogenesis AT carolinagoncalves roleofmob4incellproliferationandneurogenesis AT brunaioliveira roleofmob4incellproliferationandneurogenesis AT alvaroatavares roleofmob4incellproliferationandneurogenesis |