Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model
Helicobacter pylori (H. Pylori) is a potential pathogen found in approximately 50% of the human population, although many infected by it remain asymptomatic. The current treatment regime of it has become less effective because of antibiotic resistance. Accordingly, an alternative treatment with reas...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09540105.2019.1617251 |
| _version_ | 1819225420891947008 |
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| author | Tamanna Jahan Mony Hyuck-Se Kwon Mi-Kyoung Won Yeon-Mi Kang Su-Hee Lee Su-Yeun Kim Doo-Yeon Baek Fazle Elahi |
| author_facet | Tamanna Jahan Mony Hyuck-Se Kwon Mi-Kyoung Won Yeon-Mi Kang Su-Hee Lee Su-Yeun Kim Doo-Yeon Baek Fazle Elahi |
| author_sort | Tamanna Jahan Mony |
| collection | DOAJ |
| description | Helicobacter pylori (H. Pylori) is a potential pathogen found in approximately 50% of the human population, although many infected by it remain asymptomatic. The current treatment regime of it has become less effective because of antibiotic resistance. Accordingly, an alternative treatment with reasonable cost is essential. Urease is an important enzyme that enables the acclimation to harsh acidic conditions in the stomach. IgY implemented therapy is an attractive approach to preventing infection of H. pylori. The present study evaluated the anti-urease IgY effect on the prevention of H. pylori infection. To generate IgY, a 100 ng/ml mixture of purified urease A and B used to immunize Hyline brown hens. Anti-urease IgY was purified from egg yolks and orally administered to SPF C57BL/6 female mice that had been infected with H. pylori. The results demonstrated that anti-urease IgY has greater potential to prevent infection in mice, suggesting a rational therapeutic approach to H. pylori. |
| first_indexed | 2024-12-23T10:09:19Z |
| format | Article |
| id | doaj.art-73faf973789748788e63c3cf3de43373 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-12-23T10:09:19Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-73faf973789748788e63c3cf3de433732022-12-21T17:51:01ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432019-01-0130166267610.1080/09540105.2019.16172511617251Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse modelTamanna Jahan Mony0Hyuck-Se Kwon1Mi-Kyoung Won2Yeon-Mi Kang3Su-Hee Lee4Su-Yeun Kim5Doo-Yeon Baek6Fazle Elahi7Research Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDResearch Institute, ADBiotech CO., LTDHelicobacter pylori (H. Pylori) is a potential pathogen found in approximately 50% of the human population, although many infected by it remain asymptomatic. The current treatment regime of it has become less effective because of antibiotic resistance. Accordingly, an alternative treatment with reasonable cost is essential. Urease is an important enzyme that enables the acclimation to harsh acidic conditions in the stomach. IgY implemented therapy is an attractive approach to preventing infection of H. pylori. The present study evaluated the anti-urease IgY effect on the prevention of H. pylori infection. To generate IgY, a 100 ng/ml mixture of purified urease A and B used to immunize Hyline brown hens. Anti-urease IgY was purified from egg yolks and orally administered to SPF C57BL/6 female mice that had been infected with H. pylori. The results demonstrated that anti-urease IgY has greater potential to prevent infection in mice, suggesting a rational therapeutic approach to H. pylori.http://dx.doi.org/10.1080/09540105.2019.1617251anti-urease immunoglobinegg yolkhelicobacter pylorimouse model |
| spellingShingle | Tamanna Jahan Mony Hyuck-Se Kwon Mi-Kyoung Won Yeon-Mi Kang Su-Hee Lee Su-Yeun Kim Doo-Yeon Baek Fazle Elahi Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model Food and Agricultural Immunology anti-urease immunoglobin egg yolk helicobacter pylori mouse model |
| title | Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model |
| title_full | Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model |
| title_fullStr | Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model |
| title_full_unstemmed | Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model |
| title_short | Anti-urease immunoglobulin (IgY) from egg yolk prevents Helicobacter pylori infection in a mouse model |
| title_sort | anti urease immunoglobulin igy from egg yolk prevents helicobacter pylori infection in a mouse model |
| topic | anti-urease immunoglobin egg yolk helicobacter pylori mouse model |
| url | http://dx.doi.org/10.1080/09540105.2019.1617251 |
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