Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI
For many anticancer therapies, it would be desirable to accurately monitor and quantify tumor response early in the treatment regimen. This would allow oncologists to continue effective therapies or discontinue ineffective therapies early in the course of treatment, and hence, reduce morbidity. This...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2002-01-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558602800197 |
| _version_ | 1828290032871407616 |
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| author | Dominique Jennings B. Nicholas Hatton Jingyu Guo Jean-Philippe Galons Theodore P. Trouard Natarajan Raghunand James Marshall Robert J. Gillies |
| author_facet | Dominique Jennings B. Nicholas Hatton Jingyu Guo Jean-Philippe Galons Theodore P. Trouard Natarajan Raghunand James Marshall Robert J. Gillies |
| author_sort | Dominique Jennings |
| collection | DOAJ |
| description | For many anticancer therapies, it would be desirable to accurately monitor and quantify tumor response early in the treatment regimen. This would allow oncologists to continue effective therapies or discontinue ineffective therapies early in the course of treatment, and hence, reduce morbidity. This is especially true for second-line therapies, which have reduced response rates and increased toxicities. Previous works by others and ourselves have shown that water mobility, measured by diffusion-weighted magnetic resonance imaging (DW-MRI), increases early in tumors destined to respond to therapies. In the current communication, we further characterize the utility of DW-MRI to predict response of prostate cancer xenografts to docetaxel in SCID mice in a preclinical setting. The current data illustrate that tumor volumes and secreted prostatespecific antigen both respond strongly to docetaxel in a dose-responsive manner, and the apparent diffusion coefficient of water (ADCw) increases significantly by 2 days even at the lowest doses (10 mg/kg). The ADCw data were parsed by histogram analyses. Our results indicate that DW-MRI can be used for early detection of prostate carcinoma xenograft response to docetaxel chemotherapy. |
| first_indexed | 2024-04-13T10:30:39Z |
| format | Article |
| id | doaj.art-73fb5fe9ffa64873af0033b1ea4a318e |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-04-13T10:30:39Z |
| publishDate | 2002-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-73fb5fe9ffa64873af0033b1ea4a318e2022-12-22T02:50:11ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022002-01-014325526210.1038/sj.neo.7900225Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRIDominique Jennings0B. Nicholas Hatton1Jingyu Guo2Jean-Philippe Galons3Theodore P. Trouard4Natarajan Raghunand5James Marshall6Robert J. Gillies7Department of Biochemistry, University of Arizona Health Sciences Center, Tucson, AZ 85724, USADepartment of Biochemistry, University of Arizona Health Sciences Center, Tucson, AZ 85724, USADepartment of Physiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USADepartment of Radiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USADepartment of Radiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USAArizona Cancer Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USAArizona Cancer Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USADepartment of Biochemistry, University of Arizona Health Sciences Center, Tucson, AZ 85724, USAFor many anticancer therapies, it would be desirable to accurately monitor and quantify tumor response early in the treatment regimen. This would allow oncologists to continue effective therapies or discontinue ineffective therapies early in the course of treatment, and hence, reduce morbidity. This is especially true for second-line therapies, which have reduced response rates and increased toxicities. Previous works by others and ourselves have shown that water mobility, measured by diffusion-weighted magnetic resonance imaging (DW-MRI), increases early in tumors destined to respond to therapies. In the current communication, we further characterize the utility of DW-MRI to predict response of prostate cancer xenografts to docetaxel in SCID mice in a preclinical setting. The current data illustrate that tumor volumes and secreted prostatespecific antigen both respond strongly to docetaxel in a dose-responsive manner, and the apparent diffusion coefficient of water (ADCw) increases significantly by 2 days even at the lowest doses (10 mg/kg). The ADCw data were parsed by histogram analyses. Our results indicate that DW-MRI can be used for early detection of prostate carcinoma xenograft response to docetaxel chemotherapy.http://www.sciencedirect.com/science/article/pii/S1476558602800197diffusion-weighted MRIapparent diffusion coefficientprostate-specific antigendocetaxelprostate carcinoma |
| spellingShingle | Dominique Jennings B. Nicholas Hatton Jingyu Guo Jean-Philippe Galons Theodore P. Trouard Natarajan Raghunand James Marshall Robert J. Gillies Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI Neoplasia: An International Journal for Oncology Research diffusion-weighted MRI apparent diffusion coefficient prostate-specific antigen docetaxel prostate carcinoma |
| title | Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI |
| title_full | Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI |
| title_fullStr | Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI |
| title_full_unstemmed | Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI |
| title_short | Early Response of Prostate Carcinoma Xenografts to Docetaxel Chemotherapy Monitored With Diffusion MRI |
| title_sort | early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion mri |
| topic | diffusion-weighted MRI apparent diffusion coefficient prostate-specific antigen docetaxel prostate carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1476558602800197 |
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