SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation

SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation

Abstract.: SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-1, and B16F10) and human umbilical vein endothelia...

Full description

Bibliographic Details
Main Authors:	Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie, Lijuan Chen
Format:	Article
Language:	English
Published:	Elsevier 2014-04-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131930074X

Similar Items

PI3K/AKT/mTOR pathway in Angiogenesis
by: Jayashree eKarar, et al.
Published: (2011-12-01)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
by: Wen Wen, et al.
Published: (2020-09-01)

CSTB accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathway
by: Weiyi Zhu, et al.
Published: (2024-01-01)

Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer
by: Rajani Rai, et al.
Published: (2020-05-01)

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
by: Qingfang Li, et al.
Published: (2022-12-01)

AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
by: Ming-Chun Hung, et al.
Published: (2022-08-01)

Akt and mTOR in B cell activation and differentiation
by: David A. Fruman, et al.
Published: (2012-08-01)

Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
by: Lijun Lv, et al.
Published: (2023-03-01)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer.
by: Guo-Dong Cao, et al.
Published: (2016-01-01)

mTOR-dependent phosphorylation controls TFEB nuclear export
by: Gennaro Napolitano, et al.
Published: (2018-08-01)

ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice
by: Mengxin Shen, et al.
Published: (2022-12-01)

Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
by: Chih-Ya Wang, et al.
Published: (2012-01-01)

Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins.
by: Janna E Hutz, et al.
Published: (2011-01-01)

Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
by: Qing Wang, et al.
Published: (2023-11-01)

Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.
by: Jae Sung You, et al.
Published: (2012-01-01)

Echinacoside exhibits antidepressant-like effects through AMPAR–Akt/ERK–mTOR pathway stimulation and BDNF expression in mice
by: Han-Wen Chuang, et al.
Published: (2022-01-01)

mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes.
by: Antonia Patruno, et al.
Published: (2015-01-01)

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
by: Maikel A Farhan, et al.
Published: (2015-01-01)

Dual Target of EGFR and mTOR Suppresses Triple-Negative Breast Cancer Cell Growth by Regulating the Phosphorylation of mTOR Downstream Proteins
by: Ma J, et al.
Published: (2023-01-01)

Eriocitrin Inhibits Angiogenesis by Targeting VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways
by: Ji-Yoon Baek, et al.
Published: (2024-04-01)

Akt1 enhances CA916798 expression through mTOR pathway.
by: Yu-Liang Wang, et al.
Published: (2013-01-01)

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway
by: Jung-Min Kim, et al.
Published: (2022-08-01)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
by: Zhilin Zou, et al.
Published: (2020-03-01)

Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.
by: Dworakowska, D, et al.
Published: (2009)

Targeting PI3K/Akt/mTOR Signaling In Cancer
by: Camillo ePorta, et al.
Published: (2014-04-01)

PI3K/Akt/mTOR inhibitors in breast cancer
by: Joycelyn JX Lee, et al.
Published: (2015-12-01)

The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling
by: Ruohan Zhang, et al.
Published: (2022-02-01)

Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.
by: Zhiqing Fang, et al.
Published: (2013-01-01)

Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
by: Weiyuan Wang, et al.
Published: (2014-01-01)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
by: Xiangjin Zheng, et al.
Published: (2021-11-01)

Aggression Results in the Phosphorylation of ERK1/2 in the Nucleus Accumbens and the Dephosphorylation of mTOR in the Medial Prefrontal Cortex in Female Syrian Hamsters
by: Johnathan M. Borland, et al.
Published: (2023-01-01)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
by: Victor H. Villar, et al.
Published: (2017-05-01)

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
by: Jing Xu, et al.
Published: (2019-11-01)

Signaling Pathways mTOR and ERK as Therapeutic Targets in Sinonasal Intestinal-Type Adenocarcinoma
by: Helena Codina-Martínez, et al.
Published: (2023-10-01)

Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways.
by: Yingying Shi, et al.
Published: (2015-01-01)

Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer
by: Sanjay Mishra, et al.
Published: (2021-04-01)

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
by: Heloisa P Soares, et al.
Published: (2013-01-01)

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
by: Li Wang, et al.
Published: (2022-09-01)

PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer
by: Kunrui Zhu, et al.
Published: (2022-08-01)

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials
by: Choudhary Harsha, et al.
Published: (2020-05-01)