Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass
Abstract Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone camera as the sensing interface. By contrast, magnetics-based modalities exploiting the smartphone compass (magnetometer) remain u...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47073-2 |
| _version_ | 1797233464033935360 |
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| author | Mark Ferris Gary Zabow |
| author_facet | Mark Ferris Gary Zabow |
| author_sort | Mark Ferris |
| collection | DOAJ |
| description | Abstract Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone camera as the sensing interface. By contrast, magnetics-based modalities exploiting the smartphone compass (magnetometer) remain unexplored, despite inherent advantages in optically opaque, scattering or auto-fluorescing samples. Here we report smartphone analyte sensing utilizing the built-in magnetometer for signal transduction via analyte-responsive magnetic-hydrogel composites. As these hydrogels dilate in response to targeted stimuli, they displace attached magnetic material relative to the phone’s magnetometer. Using a bilayer hydrogel geometry to amplify this motion allows for sensitive, optics-free, quantitative liquid-based analyte measurements that require neither any electronics nor power beyond that contained within the smartphone itself. We demonstrate this concept with glucose-specific and pH-responsive hydrogels, including glucose detection down to single-digit micromolar concentrations with potential for extension to nanomolar sensitivities. The platform is adaptable to numerous measurands, opening a path towards portable, inexpensive sensing of multiple analytes or biomarkers of interest. |
| first_indexed | 2024-04-24T16:16:35Z |
| format | Article |
| id | doaj.art-73fbe4fd83a1496b9525abe529ea22b9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T16:16:35Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-73fbe4fd83a1496b9525abe529ea22b92024-03-31T11:24:53ZengNature PortfolioNature Communications2041-17232024-03-0115111010.1038/s41467-024-47073-2Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compassMark Ferris0Gary Zabow1Applied Physics Division, National Institute of Standards and TechnologyApplied Physics Division, National Institute of Standards and TechnologyAbstract Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone camera as the sensing interface. By contrast, magnetics-based modalities exploiting the smartphone compass (magnetometer) remain unexplored, despite inherent advantages in optically opaque, scattering or auto-fluorescing samples. Here we report smartphone analyte sensing utilizing the built-in magnetometer for signal transduction via analyte-responsive magnetic-hydrogel composites. As these hydrogels dilate in response to targeted stimuli, they displace attached magnetic material relative to the phone’s magnetometer. Using a bilayer hydrogel geometry to amplify this motion allows for sensitive, optics-free, quantitative liquid-based analyte measurements that require neither any electronics nor power beyond that contained within the smartphone itself. We demonstrate this concept with glucose-specific and pH-responsive hydrogels, including glucose detection down to single-digit micromolar concentrations with potential for extension to nanomolar sensitivities. The platform is adaptable to numerous measurands, opening a path towards portable, inexpensive sensing of multiple analytes or biomarkers of interest.https://doi.org/10.1038/s41467-024-47073-2 |
| spellingShingle | Mark Ferris Gary Zabow Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass Nature Communications |
| title | Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass |
| title_full | Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass |
| title_fullStr | Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass |
| title_full_unstemmed | Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass |
| title_short | Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass |
| title_sort | quantitative high sensitivity measurement of liquid analytes using a smartphone compass |
| url | https://doi.org/10.1038/s41467-024-47073-2 |
| work_keys_str_mv | AT markferris quantitativehighsensitivitymeasurementofliquidanalytesusingasmartphonecompass AT garyzabow quantitativehighsensitivitymeasurementofliquidanalytesusingasmartphonecompass |