DDX3X: structure, physiologic functions and cancer
Abstract The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-02-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-021-01325-7 |
| _version_ | 1818370283043553280 |
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| author | Jie Mo Huifang Liang Chen Su Pengcheng Li Jin Chen Bixiang Zhang |
| author_facet | Jie Mo Huifang Liang Chen Su Pengcheng Li Jin Chen Bixiang Zhang |
| author_sort | Jie Mo |
| collection | DOAJ |
| description | Abstract The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role of DDX3X in tumorigenesis and tumour progression. In fact, DDX3X possesses numerous functions in cancer biology and is closely related to many well-known molecules. In this review, we describe the function of DDX3X in RNA metabolism, cellular stress response, innate immune response, metabolic stress response in pancreatic β cells and embryo development. Then, we focused on the role of DDX3X in cancer biology and systematically demonstrated its functions in various aspects of tumorigenesis and development. To provide a more intuitive understanding of the role of DDX3X in cancer, we summarized its functions and specific mechanisms in various types of cancer and presented its involvement in cancer-related signalling pathways. |
| first_indexed | 2024-12-13T23:37:16Z |
| format | Article |
| id | doaj.art-73fcf5049f0b4631aa6dda07e54ab6e1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-13T23:37:16Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-73fcf5049f0b4631aa6dda07e54ab6e12022-12-21T23:27:16ZengBMCMolecular Cancer1476-45982021-02-0120112010.1186/s12943-021-01325-7DDX3X: structure, physiologic functions and cancerJie Mo0Huifang Liang1Chen Su2Pengcheng Li3Jin Chen4Bixiang Zhang5Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesAbstract The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role of DDX3X in tumorigenesis and tumour progression. In fact, DDX3X possesses numerous functions in cancer biology and is closely related to many well-known molecules. In this review, we describe the function of DDX3X in RNA metabolism, cellular stress response, innate immune response, metabolic stress response in pancreatic β cells and embryo development. Then, we focused on the role of DDX3X in cancer biology and systematically demonstrated its functions in various aspects of tumorigenesis and development. To provide a more intuitive understanding of the role of DDX3X in cancer, we summarized its functions and specific mechanisms in various types of cancer and presented its involvement in cancer-related signalling pathways.https://doi.org/10.1186/s12943-021-01325-7DDX3XRNA metabolismCancer |
| spellingShingle | Jie Mo Huifang Liang Chen Su Pengcheng Li Jin Chen Bixiang Zhang DDX3X: structure, physiologic functions and cancer Molecular Cancer DDX3X RNA metabolism Cancer |
| title | DDX3X: structure, physiologic functions and cancer |
| title_full | DDX3X: structure, physiologic functions and cancer |
| title_fullStr | DDX3X: structure, physiologic functions and cancer |
| title_full_unstemmed | DDX3X: structure, physiologic functions and cancer |
| title_short | DDX3X: structure, physiologic functions and cancer |
| title_sort | ddx3x structure physiologic functions and cancer |
| topic | DDX3X RNA metabolism Cancer |
| url | https://doi.org/10.1186/s12943-021-01325-7 |
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