Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. Surprisingly, the mouse circadian clock can function independent of PER phosphorylation and PER abundance rhythms.

Bibliographic Details
Main Authors: Yang An, Baoshi Yuan, Pancheng Xie, Yue Gu, Zhiwei Liu, Tao Wang, Zhihao Li, Ying Xu, Yi Liu
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31715-4

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