Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study
Objectives: This study aimed to evaluate the long-term antibody kinetics after vaccinating with an inactivated COVID-19 Vero cell vaccine (CoronaVac) in healthcare workers (HCWs) at a single center in Turkey. Methods: For this prospective observational study, Chemiluminescence immunoassay (CLIA) and...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222002715 |
| _version_ | 1798032358909149184 |
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| author | Yesim Yildiz Hasan Selcuk Ozger Esin Senol Resul Karakus Merve Buyukkoruk Fatma Betul Altin Fatma Zehra Ozcan Melek Yaman Nihan Oruklu Aysegul Atak Yucel Emin Umit Bagriacik |
| author_facet | Yesim Yildiz Hasan Selcuk Ozger Esin Senol Resul Karakus Merve Buyukkoruk Fatma Betul Altin Fatma Zehra Ozcan Melek Yaman Nihan Oruklu Aysegul Atak Yucel Emin Umit Bagriacik |
| author_sort | Yesim Yildiz |
| collection | DOAJ |
| description | Objectives: This study aimed to evaluate the long-term antibody kinetics after vaccinating with an inactivated COVID-19 Vero cell vaccine (CoronaVac) in healthcare workers (HCWs) at a single center in Turkey. Methods: For this prospective observational study, Chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) were used for the determination of binding antibodies (bAb) and neutralizing antibodies (nAb), respectively. Antibody kinetics were compared for the potential influencing factors, and propensity score analysis was performed to match the subcohort for age. Results: Early bAb and nAb response was achieved in all 343 participants. Titers of bAbs against SARS-CoV-2 on 42 days post-vaccination (dpv) were higher in HCWs who were aged <40 years and who had a history of COVID-19. SARS-CoV-2 bAb levels in HCWs on days 42 (n = 97), 90 (n = 97), and 180 (n = 97) were 175 IU/ml (3.9-250), 107 IU/ml (2.4-250), and 66.1 IU/ml (2.57-250), respectively (p<0.001). SARS-CoV-2 bAb (p<0.001) and nAb (p<0.001) titers decreased significantly over time. There was a high negative correlation between SARS-CoV-2 antibody titers and inverse optic density of nAb responses (Pearson correlation coefficient: -0.738, p<0.001). Conclusions: When the antibody responses were compared, it was seen that the vaccine immunogenicity was better in those who had prior COVID-19 history and were aged <40 years. In the course of time, it was determined that there was a significant decrease in bAb and nAb responses after the 90th day. These results may guide approval decisions for booster COVID-19 vaccines. |
| first_indexed | 2024-04-11T20:11:51Z |
| format | Article |
| id | doaj.art-73febc841d2e4629983304ab4c4036a3 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T20:11:51Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-73febc841d2e4629983304ab4c4036a32022-12-22T04:05:05ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-0112299106Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational studyYesim Yildiz0Hasan Selcuk Ozger1Esin Senol2Resul Karakus3Merve Buyukkoruk4Fatma Betul Altin5Fatma Zehra Ozcan6Melek Yaman7Nihan Oruklu8Aysegul Atak Yucel9Emin Umit Bagriacik10Department of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey; Corresponding author: Yesim Yildiz.Department of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, TurkeyDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, TurkeyObjectives: This study aimed to evaluate the long-term antibody kinetics after vaccinating with an inactivated COVID-19 Vero cell vaccine (CoronaVac) in healthcare workers (HCWs) at a single center in Turkey. Methods: For this prospective observational study, Chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) were used for the determination of binding antibodies (bAb) and neutralizing antibodies (nAb), respectively. Antibody kinetics were compared for the potential influencing factors, and propensity score analysis was performed to match the subcohort for age. Results: Early bAb and nAb response was achieved in all 343 participants. Titers of bAbs against SARS-CoV-2 on 42 days post-vaccination (dpv) were higher in HCWs who were aged <40 years and who had a history of COVID-19. SARS-CoV-2 bAb levels in HCWs on days 42 (n = 97), 90 (n = 97), and 180 (n = 97) were 175 IU/ml (3.9-250), 107 IU/ml (2.4-250), and 66.1 IU/ml (2.57-250), respectively (p<0.001). SARS-CoV-2 bAb (p<0.001) and nAb (p<0.001) titers decreased significantly over time. There was a high negative correlation between SARS-CoV-2 antibody titers and inverse optic density of nAb responses (Pearson correlation coefficient: -0.738, p<0.001). Conclusions: When the antibody responses were compared, it was seen that the vaccine immunogenicity was better in those who had prior COVID-19 history and were aged <40 years. In the course of time, it was determined that there was a significant decrease in bAb and nAb responses after the 90th day. These results may guide approval decisions for booster COVID-19 vaccines.http://www.sciencedirect.com/science/article/pii/S1201971222002715 |
| spellingShingle | Yesim Yildiz Hasan Selcuk Ozger Esin Senol Resul Karakus Merve Buyukkoruk Fatma Betul Altin Fatma Zehra Ozcan Melek Yaman Nihan Oruklu Aysegul Atak Yucel Emin Umit Bagriacik Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study International Journal of Infectious Diseases |
| title | Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study |
| title_full | Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study |
| title_fullStr | Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study |
| title_full_unstemmed | Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study |
| title_short | Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational study |
| title_sort | evaluation of long term antibody kinetics in healthcare workers vaccinated with inactivated covid 19 vero cell vaccine coronavac a propensity score matched observational study |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222002715 |
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