Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis
Introduction: Although patients with diffuse idiopathic skeletal hyperostosis (DISH) do not have low bone density, it is a risk factor for spine fractures associated with DISH. We investigated the characteristics and bone metabolism markers of patients with DISH having low bone density to assess whe...
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| Format: | Article |
| Language: | English |
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The Japanese Society for Spine Surgery and Related Research
2022-09-01
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| Series: | Spine Surgery and Related Research |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/ssrr/6/5/6_2021-0149/_pdf/-char/en |
| _version_ | 1811241641317498880 |
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| author | Mitsuru Furukawa Kunimasa Okuyama Ken Ninomiya Takeshi Miyamoto Yoshiyuki Yato |
| author_facet | Mitsuru Furukawa Kunimasa Okuyama Ken Ninomiya Takeshi Miyamoto Yoshiyuki Yato |
| author_sort | Mitsuru Furukawa |
| collection | DOAJ |
| description | Introduction: Although patients with diffuse idiopathic skeletal hyperostosis (DISH) do not have low bone density, it is a risk factor for spine fractures associated with DISH. We investigated the characteristics and bone metabolism markers of patients with DISH having low bone density to assess whether osteoporosis medication is necessary to prevent fractures.
Methods: A cross-sectional study was conducted between April 1, 2008, and March 31, 2019. The 86 patients included were divided into two groups according to their T-scores―one group had low bone density and DISH, and the other group did not. Group A (T-score−1) and B (T-score>−1) data were adjusted for confounding factors and compared for differences in age, body weight, maximum number of vertebral bodies with bony bridges between adjacent vertebrae (max VB), and previous history (hypertension, malignant tumors, diabetes mellitus, cardiac diseases, chronic renal failure, and spinal fractures). In Group A, multiple linear regression was used to investigate relationships among max VB, femur bone mineral density (BMD), total type I procollagen N-terminal propeptide (P1NP), and tartrate-resistant acid phosphatase 5b (TRACP-5b).
Results: Group A had 36, and Group B had 50 male patients with DISH. Patients in Group B were heavier than those in Group A. The mean femur BMD in Group A was age-appropriate, and that in Group B was higher than the age-appropriate femur BMD. The mean values of P1NP and TRACP-5b were within the normal range. Max VB was positively correlated with total P1NP in Group A. Total P1NP was significantly and positively correlated with TRACP-5b.
Conclusions: The DISH group with a T-score of −1 was age-appropriate. The group with a T-score of >−1 had higher BMD because of their higher body weight. The group with a T-score of −1 had good bone metabolism and did not require aggressive osteoporosis treatment. |
| first_indexed | 2024-04-12T13:39:01Z |
| format | Article |
| id | doaj.art-7401dab1bfda41a2a032ed900cab72e2 |
| institution | Directory Open Access Journal |
| issn | 2432-261X |
| language | English |
| last_indexed | 2024-04-12T13:39:01Z |
| publishDate | 2022-09-01 |
| publisher | The Japanese Society for Spine Surgery and Related Research |
| record_format | Article |
| series | Spine Surgery and Related Research |
| spelling | doaj.art-7401dab1bfda41a2a032ed900cab72e22022-12-22T03:30:54ZengThe Japanese Society for Spine Surgery and Related ResearchSpine Surgery and Related Research2432-261X2022-09-016552653210.22603/ssrr.2021-01492021-0149Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal HyperostosisMitsuru Furukawa0Kunimasa Okuyama1Ken Ninomiya2Takeshi Miyamoto3Yoshiyuki Yato4Department of Orthopedic Surgery, Murayama Medical CenterDepartment of Orthopedic Surgery, Shizuoka City Shimizu HospitalDepartment of Orthopedic Surgery, Shizuoka City Shimizu HospitalDepartment of Orthopedic Surgery, Kumamoto UniversityDepartment of Orthopedic Surgery, Murayama Medical CenterIntroduction: Although patients with diffuse idiopathic skeletal hyperostosis (DISH) do not have low bone density, it is a risk factor for spine fractures associated with DISH. We investigated the characteristics and bone metabolism markers of patients with DISH having low bone density to assess whether osteoporosis medication is necessary to prevent fractures. Methods: A cross-sectional study was conducted between April 1, 2008, and March 31, 2019. The 86 patients included were divided into two groups according to their T-scores―one group had low bone density and DISH, and the other group did not. Group A (T-score−1) and B (T-score>−1) data were adjusted for confounding factors and compared for differences in age, body weight, maximum number of vertebral bodies with bony bridges between adjacent vertebrae (max VB), and previous history (hypertension, malignant tumors, diabetes mellitus, cardiac diseases, chronic renal failure, and spinal fractures). In Group A, multiple linear regression was used to investigate relationships among max VB, femur bone mineral density (BMD), total type I procollagen N-terminal propeptide (P1NP), and tartrate-resistant acid phosphatase 5b (TRACP-5b). Results: Group A had 36, and Group B had 50 male patients with DISH. Patients in Group B were heavier than those in Group A. The mean femur BMD in Group A was age-appropriate, and that in Group B was higher than the age-appropriate femur BMD. The mean values of P1NP and TRACP-5b were within the normal range. Max VB was positively correlated with total P1NP in Group A. Total P1NP was significantly and positively correlated with TRACP-5b. Conclusions: The DISH group with a T-score of −1 was age-appropriate. The group with a T-score of >−1 had higher BMD because of their higher body weight. The group with a T-score of −1 had good bone metabolism and did not require aggressive osteoporosis treatment.https://www.jstage.jst.go.jp/article/ssrr/6/5/6_2021-0149/_pdf/-char/enbone mineral densitydiffuse idiopathic skeletal hyperostosisproximal femurtype i procollagen n-terminal propeptide |
| spellingShingle | Mitsuru Furukawa Kunimasa Okuyama Ken Ninomiya Takeshi Miyamoto Yoshiyuki Yato Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis Spine Surgery and Related Research bone mineral density diffuse idiopathic skeletal hyperostosis proximal femur type i procollagen n-terminal propeptide |
| title | Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis |
| title_full | Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis |
| title_fullStr | Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis |
| title_full_unstemmed | Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis |
| title_short | Assessment of the Necessity of Osteoporosis Treatment for Patients with Low Bone Density in Diffuse Idiopathic Skeletal Hyperostosis |
| title_sort | assessment of the necessity of osteoporosis treatment for patients with low bone density in diffuse idiopathic skeletal hyperostosis |
| topic | bone mineral density diffuse idiopathic skeletal hyperostosis proximal femur type i procollagen n-terminal propeptide |
| url | https://www.jstage.jst.go.jp/article/ssrr/6/5/6_2021-0149/_pdf/-char/en |
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