Microbiome Composition and Its Impact on the Development of Allergic Diseases
Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00700/full |
| _version_ | 1828177284535681024 |
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| author | Diego G. Peroni Giulia Nuzzi Irene Trambusti Maria Elisa Di Cicco Pasquale Comberiati Pasquale Comberiati |
| author_facet | Diego G. Peroni Giulia Nuzzi Irene Trambusti Maria Elisa Di Cicco Pasquale Comberiati Pasquale Comberiati |
| author_sort | Diego G. Peroni |
| collection | DOAJ |
| description | Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells play a pivotal role in the development of the immune system. Therefore, the process of early colonization by a “healthy” microbiome is emerging as a key determinant of life-long health. In stark contrast, the perturbation of such a process, which results in changes in the host-microbiome biodiversity and metabolic activities, has been associated with greater susceptibility to immune-mediated disorders later in life, including allergic diseases. Here, we outline recent findings on the potential contribution of the microbiome in the gastrointestinal tract, skin, and airways to the development of FA, AD, and asthma. Furthermore, we address how the modulation of the microbiome composition in these different body districts could be a potential strategy for the prevention and treatment of allergic diseases. |
| first_indexed | 2024-04-12T04:56:54Z |
| format | Article |
| id | doaj.art-74024688358d4bb3b843c72364720004 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T04:56:54Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-74024688358d4bb3b843c723647200042022-12-22T03:47:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-04-011110.3389/fimmu.2020.00700526671Microbiome Composition and Its Impact on the Development of Allergic DiseasesDiego G. Peroni0Giulia Nuzzi1Irene Trambusti2Maria Elisa Di Cicco3Pasquale Comberiati4Pasquale Comberiati5Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyDepartment of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow, RussiaAllergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes both on a macro and micro scale, which have led to reduced microbial exposure in early life and perturbation of the human microbiome composition. Increasing evidence shows that early life interactions between the human microbiome and the immune cells play a pivotal role in the development of the immune system. Therefore, the process of early colonization by a “healthy” microbiome is emerging as a key determinant of life-long health. In stark contrast, the perturbation of such a process, which results in changes in the host-microbiome biodiversity and metabolic activities, has been associated with greater susceptibility to immune-mediated disorders later in life, including allergic diseases. Here, we outline recent findings on the potential contribution of the microbiome in the gastrointestinal tract, skin, and airways to the development of FA, AD, and asthma. Furthermore, we address how the modulation of the microbiome composition in these different body districts could be a potential strategy for the prevention and treatment of allergic diseases.https://www.frontiersin.org/article/10.3389/fimmu.2020.00700/fullallergyasthmaatopic dermatitisfood allergyhealth outcomesimmune system |
| spellingShingle | Diego G. Peroni Giulia Nuzzi Irene Trambusti Maria Elisa Di Cicco Pasquale Comberiati Pasquale Comberiati Microbiome Composition and Its Impact on the Development of Allergic Diseases Frontiers in Immunology allergy asthma atopic dermatitis food allergy health outcomes immune system |
| title | Microbiome Composition and Its Impact on the Development of Allergic Diseases |
| title_full | Microbiome Composition and Its Impact on the Development of Allergic Diseases |
| title_fullStr | Microbiome Composition and Its Impact on the Development of Allergic Diseases |
| title_full_unstemmed | Microbiome Composition and Its Impact on the Development of Allergic Diseases |
| title_short | Microbiome Composition and Its Impact on the Development of Allergic Diseases |
| title_sort | microbiome composition and its impact on the development of allergic diseases |
| topic | allergy asthma atopic dermatitis food allergy health outcomes immune system |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00700/full |
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