Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report
A 24-year-old male suffered from acute-onset right-sided hemiparesis, dysarthria, and ophthalmoplegia in February 2001. Brain magnetic resonance imaging revealed a cavernous angioma with hemorrhage over the left thalamus. Moreover, some rhythmic, coarse, low-frequency (2-3 Hz) oscillation over the r...
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| Format: | Article |
| Language: | English |
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Wiley
2006-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09702359 |
| _version_ | 1819106979076898816 |
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| author | Li-Min Liou Pang-Ying Shih |
| author_facet | Li-Min Liou Pang-Ying Shih |
| author_sort | Li-Min Liou |
| collection | DOAJ |
| description | A 24-year-old male suffered from acute-onset right-sided hemiparesis, dysarthria, and ophthalmoplegia in February 2001. Brain magnetic resonance imaging revealed a cavernous angioma with hemorrhage over the left thalamus. Moreover, some rhythmic, coarse, low-frequency (2-3 Hz) oscillation over the right wrist and elbow was noted 1 month later. Action tremor was more predominant than resting tremor. Rubral tremor was diagnosed on the basis of the clinical presentation and tremography analysis. Rubral tremor is not unusual, and pharmacotherapy is nearly always ineffective in clinical practice. Deep brain stimulation, thalamotomy, and pallidotomy are all considered effective according to recent research. However, they are either very expensive or invasive, and involve surgical risks. In our patient, we tried valproate, clonazepam, and verapamil one after another, but all in vain. Finally, titration of trihexyphenidyl provided significant benefit. The tremor was successfully controlled by a single high daily dose of trihexyphenidyl (38 mg) without severe or uncomfortable side effects. Here, we report a case of successful monotherapy of rubral tremor with high-dose trihexyphenidyl. |
| first_indexed | 2024-12-22T02:46:44Z |
| format | Article |
| id | doaj.art-7402daac88024aa99e5cf8f246f1ddfc |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-22T02:46:44Z |
| publishDate | 2006-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-7402daac88024aa99e5cf8f246f1ddfc2022-12-21T18:41:29ZengWileyKaohsiung Journal of Medical Sciences1607-551X2006-03-0122314915310.1016/S1607-551X(09)70235-9Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case ReportLi-Min Liou0Pang-Ying Shih1Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanA 24-year-old male suffered from acute-onset right-sided hemiparesis, dysarthria, and ophthalmoplegia in February 2001. Brain magnetic resonance imaging revealed a cavernous angioma with hemorrhage over the left thalamus. Moreover, some rhythmic, coarse, low-frequency (2-3 Hz) oscillation over the right wrist and elbow was noted 1 month later. Action tremor was more predominant than resting tremor. Rubral tremor was diagnosed on the basis of the clinical presentation and tremography analysis. Rubral tremor is not unusual, and pharmacotherapy is nearly always ineffective in clinical practice. Deep brain stimulation, thalamotomy, and pallidotomy are all considered effective according to recent research. However, they are either very expensive or invasive, and involve surgical risks. In our patient, we tried valproate, clonazepam, and verapamil one after another, but all in vain. Finally, titration of trihexyphenidyl provided significant benefit. The tremor was successfully controlled by a single high daily dose of trihexyphenidyl (38 mg) without severe or uncomfortable side effects. Here, we report a case of successful monotherapy of rubral tremor with high-dose trihexyphenidyl.http://www.sciencedirect.com/science/article/pii/S1607551X09702359rubral tremorpharmacotherapytrihexyphenidyl |
| spellingShingle | Li-Min Liou Pang-Ying Shih Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report Kaohsiung Journal of Medical Sciences rubral tremor pharmacotherapy trihexyphenidyl |
| title | Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report |
| title_full | Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report |
| title_fullStr | Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report |
| title_full_unstemmed | Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report |
| title_short | Successful Treatment of Rubral Tremor by High-Dose Trihexyphenidyl: A Case Report |
| title_sort | successful treatment of rubral tremor by high dose trihexyphenidyl a case report |
| topic | rubral tremor pharmacotherapy trihexyphenidyl |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09702359 |
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