Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement
Primary cardiac lymphoma is extremely uncommon. We report a case of a 54 year old Caucasian male with a history of non-small cell lung cancer treated by surgical resection who presented with chest pain and dyspnea on exertion. Computerized tomography (CT) imaging confirmed a 7.8¥3.8 cm right atrial...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/2713 |
| _version_ | 1797936042036166656 |
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| author | Lisa M. Lepeak David T. Yang Julie E. Chang |
| author_facet | Lisa M. Lepeak David T. Yang Julie E. Chang |
| author_sort | Lisa M. Lepeak |
| collection | DOAJ |
| description | Primary cardiac lymphoma is extremely uncommon. We report a case of a 54 year old Caucasian male with a history of non-small cell lung cancer treated by surgical resection who presented with chest pain and dyspnea on exertion. Computerized tomography (CT) imaging confirmed a 7.8¥3.8 cm right atrial soft tissue mass infiltrating the lateral wall of the right atrium, and a 5 cm pericardiophrenic mass. Echocardiography confirmed a moderate pericardial effusion without tamponade physiology. Percutaneous biopsy of the pericardiophrenic mass revealed pathologic features diagnostic of NK/T-cell lymphoma. He received CHOP chemotherapy with some improvement in symptoms, but experienced radiographic progression after 2 cycles. He received palliative involved field radiotherapy but developed new sites of progressive disease within the abdomen and died shortly after completing radiotherapy. NK/T-cell lymphomas are aggressive tumors that may present with unusual extranodal disease sites. Prompt diagnosis with consideration for referral to a specialty center with experience in treatment of these rare tumors may offer the greatest potential for improving treatment outcomes. |
| first_indexed | 2024-04-10T18:23:27Z |
| format | Article |
| id | doaj.art-74032021e08b401d9f9fa29bdc9de7d9 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:23:27Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-74032021e08b401d9f9fa29bdc9de7d92023-02-02T06:43:48ZengMDPI AGHematology Reports2038-83222038-83302011-08-0132e9e910.4081/hr.2011.e91586Extranodal NK/T-cell lymphoma presenting with primary cardiac involvementLisa M. Lepeak0David T. YangJulie E. ChangUniversity of Wisconsin School of Medicine and Public HealthPrimary cardiac lymphoma is extremely uncommon. We report a case of a 54 year old Caucasian male with a history of non-small cell lung cancer treated by surgical resection who presented with chest pain and dyspnea on exertion. Computerized tomography (CT) imaging confirmed a 7.8¥3.8 cm right atrial soft tissue mass infiltrating the lateral wall of the right atrium, and a 5 cm pericardiophrenic mass. Echocardiography confirmed a moderate pericardial effusion without tamponade physiology. Percutaneous biopsy of the pericardiophrenic mass revealed pathologic features diagnostic of NK/T-cell lymphoma. He received CHOP chemotherapy with some improvement in symptoms, but experienced radiographic progression after 2 cycles. He received palliative involved field radiotherapy but developed new sites of progressive disease within the abdomen and died shortly after completing radiotherapy. NK/T-cell lymphomas are aggressive tumors that may present with unusual extranodal disease sites. Prompt diagnosis with consideration for referral to a specialty center with experience in treatment of these rare tumors may offer the greatest potential for improving treatment outcomes.http://www.pagepress.org/journals/index.php/hr/article/view/2713HematologyLymphomaCardiac |
| spellingShingle | Lisa M. Lepeak David T. Yang Julie E. Chang Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement Hematology Reports Hematology Lymphoma Cardiac |
| title | Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement |
| title_full | Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement |
| title_fullStr | Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement |
| title_full_unstemmed | Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement |
| title_short | Extranodal NK/T-cell lymphoma presenting with primary cardiac involvement |
| title_sort | extranodal nk t cell lymphoma presenting with primary cardiac involvement |
| topic | Hematology Lymphoma Cardiac |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/2713 |
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