The Impact of α-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo

The Impact of α-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo

The duodenal mucosa is regularly exposed to a low osmolality, and recent experiments suggest that hypotonicity increases mucosal permeability in an osmolality-dependent manner. The aim was to examine whether the sympathetic nervous system, via action on α-adrenoceptors, affects the hypotonicity-indu...

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Bibliographic Details
Main Authors: John Sedin, David Dahlgren, Markus Sjöblom, Olof Nylander
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
luminal osmolality
mucosal permeability
α-adrenoceptor agonists
α-adrenoceptor antagonists
COX-2
clonidine
Online Access:https://www.mdpi.com/1999-4923/13/12/2096

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