Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing
Insulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. The aim of this study was to review the literature...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Medical Sciences Forum |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9992/21/1/17 |
| _version_ | 1797379853634240512 |
|---|---|
| author | Aneta Ostróżka-Cieślik Marcin Przybyła Weronika Wójcik Klaudia Birówka Marta Majczyna Barbara Dolińska |
| author_facet | Aneta Ostróżka-Cieślik Marcin Przybyła Weronika Wójcik Klaudia Birówka Marta Majczyna Barbara Dolińska |
| author_sort | Aneta Ostróżka-Cieślik |
| collection | DOAJ |
| description | Insulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. The aim of this study was to review the literature on the development of a hydrogel formulation of insulin to promote wound healing. An analysis of papers published between 2000 and 2022 was carried out. Embase, Medline, PubMed, and Cochrane Library databases were used. Hydrogels may provide a starting point for developing new products or improving the efficacy of designed epidermal forms of insulin. The hydrogels used allow efficient delivery of the peptide into the wound environment. |
| first_indexed | 2024-03-08T20:29:02Z |
| format | Article |
| id | doaj.art-740411d1ad6249dbaa8eb1de38d1f301 |
| institution | Directory Open Access Journal |
| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-08T20:29:02Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-740411d1ad6249dbaa8eb1de38d1f3012023-12-22T14:28:41ZengMDPI AGMedical Sciences Forum2673-99922023-03-012111710.3390/ECB2023-14290Review of Research in Developing Hydrogels with Insulin to Promote Wound HealingAneta Ostróżka-Cieślik0Marcin Przybyła1Weronika Wójcik2Klaudia Birówka3Marta Majczyna4Barbara Dolińska5Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandInsulin affects wound healing by reducing inflammation, regulating oxidative reactions, and increasing collagen deposition. Despite the many benefits of insulin, there is still no topical product for insulin delivery through the skin on the market. The aim of this study was to review the literature on the development of a hydrogel formulation of insulin to promote wound healing. An analysis of papers published between 2000 and 2022 was carried out. Embase, Medline, PubMed, and Cochrane Library databases were used. Hydrogels may provide a starting point for developing new products or improving the efficacy of designed epidermal forms of insulin. The hydrogels used allow efficient delivery of the peptide into the wound environment.https://www.mdpi.com/2673-9992/21/1/17hydrogelpolymersinsulintopicaldiabetic ulcerswound healing |
| spellingShingle | Aneta Ostróżka-Cieślik Marcin Przybyła Weronika Wójcik Klaudia Birówka Marta Majczyna Barbara Dolińska Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing Medical Sciences Forum hydrogel polymers insulin topical diabetic ulcers wound healing |
| title | Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing |
| title_full | Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing |
| title_fullStr | Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing |
| title_full_unstemmed | Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing |
| title_short | Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing |
| title_sort | review of research in developing hydrogels with insulin to promote wound healing |
| topic | hydrogel polymers insulin topical diabetic ulcers wound healing |
| url | https://www.mdpi.com/2673-9992/21/1/17 |
| work_keys_str_mv | AT anetaostrozkacieslik reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing AT marcinprzybyła reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing AT weronikawojcik reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing AT klaudiabirowka reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing AT martamajczyna reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing AT barbaradolinska reviewofresearchindevelopinghydrogelswithinsulintopromotewoundhealing |