Efficacy and safety of purified starch for adhesion prevention in colorectal surgery
Background: Adhesions within the abdominal cavity develop in as many as 90 % of individuals following abdominal surgery. However, the true adhesive condition of patients can only be ascertained during the second surgery. Methods: We conducted a prospective, non-randomized study to assess the anti-ad...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023088655 |
| _version_ | 1797429852814442496 |
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| author | Tzu-Min Liu Kee-Thai Kiu Min-Hsuan Yen Ka-Wai Tam Tung-Cheng Chang |
| author_facet | Tzu-Min Liu Kee-Thai Kiu Min-Hsuan Yen Ka-Wai Tam Tung-Cheng Chang |
| author_sort | Tzu-Min Liu |
| collection | DOAJ |
| description | Background: Adhesions within the abdominal cavity develop in as many as 90 % of individuals following abdominal surgery. However, the true adhesive condition of patients can only be ascertained during the second surgery. Methods: We conducted a prospective, non-randomized study to assess the anti-adhesion properties of purified starch in patients who had undergone colorectal surgery in the past and then needed a subsequent surgical intervention. Adhesion scores have been prospectively recorded in operation notes since January 2020 when patients underwent a second surgery. Patients who had received purified starch during their initial surgery constituted the purified starch group, while those who had not received anti-adhesion medical materials were the control group. The main objectives of the study were to evaluate the extent and severity of adhesions as primary outcomes, while secondary outcomes included measuring blood loss, operation time, and postoperative complications. Results: We analyzed the data of 101 patients, with 61 in the purified starch group and 40 in the control group. In multivariate analysis, adhesion severity (Odds ratio, 0.20, 95 % confidence interval 0.08–0.54, P < 0.01) and adhesion area scores (Odds ratio, 0.13, 95 % confidence interval 0.04–0.45, P < 0.01) were significantly lower in the purified starch group than in the control group. There was no significant difference in operation times, blood loss, and postoperative complications between the two groups. Conclusion: Purified starch is a safe and effective anti-adhesion material that can significantly reduce the severity and extent of adhesion after colorectal surgery. |
| first_indexed | 2024-03-09T09:18:53Z |
| format | Article |
| id | doaj.art-74047177aecd43c3974eb102ab619b0a |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:18:53Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-74047177aecd43c3974eb102ab619b0a2023-12-02T07:03:39ZengElsevierHeliyon2405-84402023-11-01911e21657Efficacy and safety of purified starch for adhesion prevention in colorectal surgeryTzu-Min Liu0Kee-Thai Kiu1Min-Hsuan Yen2Ka-Wai Tam3Tung-Cheng Chang4Department of General Medicine, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei City, 112, TaiwanDivision of Colorectal Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei Medical University, Number 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, TaiwanDivision of Colorectal Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei Medical University, Number 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, TaiwanDivision of General Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei Medical University, Number 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, Taiwan; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan; Cochrane Taiwan, Taipei Medical University, Taipei City, TaiwanDivision of Colorectal Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei Medical University, Number 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, Taiwan; Division of Colorectal Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan; Corresponding author. Division of Colorectal Surgery, Department of Surgery, Shuang-Ho Hospital, Taipei Medical University, Address: No 291, Zhongzheng Road, Zhonghe District, New Taipei City, 235, Taiwan.Background: Adhesions within the abdominal cavity develop in as many as 90 % of individuals following abdominal surgery. However, the true adhesive condition of patients can only be ascertained during the second surgery. Methods: We conducted a prospective, non-randomized study to assess the anti-adhesion properties of purified starch in patients who had undergone colorectal surgery in the past and then needed a subsequent surgical intervention. Adhesion scores have been prospectively recorded in operation notes since January 2020 when patients underwent a second surgery. Patients who had received purified starch during their initial surgery constituted the purified starch group, while those who had not received anti-adhesion medical materials were the control group. The main objectives of the study were to evaluate the extent and severity of adhesions as primary outcomes, while secondary outcomes included measuring blood loss, operation time, and postoperative complications. Results: We analyzed the data of 101 patients, with 61 in the purified starch group and 40 in the control group. In multivariate analysis, adhesion severity (Odds ratio, 0.20, 95 % confidence interval 0.08–0.54, P < 0.01) and adhesion area scores (Odds ratio, 0.13, 95 % confidence interval 0.04–0.45, P < 0.01) were significantly lower in the purified starch group than in the control group. There was no significant difference in operation times, blood loss, and postoperative complications between the two groups. Conclusion: Purified starch is a safe and effective anti-adhesion material that can significantly reduce the severity and extent of adhesion after colorectal surgery.http://www.sciencedirect.com/science/article/pii/S2405844023088655Colorectal surgeryPurified starchAbdominal adhesionPrevention |
| spellingShingle | Tzu-Min Liu Kee-Thai Kiu Min-Hsuan Yen Ka-Wai Tam Tung-Cheng Chang Efficacy and safety of purified starch for adhesion prevention in colorectal surgery Heliyon Colorectal surgery Purified starch Abdominal adhesion Prevention |
| title | Efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| title_full | Efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| title_fullStr | Efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| title_full_unstemmed | Efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| title_short | Efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| title_sort | efficacy and safety of purified starch for adhesion prevention in colorectal surgery |
| topic | Colorectal surgery Purified starch Abdominal adhesion Prevention |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023088655 |
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