A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer

A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer

Background: Radiofrequency ablation (RFA) is an established treatment option for malignancies located in the liver. RFA-induced irreversible coagulation necrosis leads to the release of danger signals and cellular content. Hence, RFA may constitute an endogenous in situ tumor vaccination, stimulatin...

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Bibliographic Details
Main Authors: Markus W. Löffler, Bianca Nussbaum, Günter Jäger, Philipp S. Jurmeister, Jan Budczies, Philippe L. Pereira, Stephan Clasen, Daniel J. Kowalewski, Lena Mühlenbruch, Ingmar Königsrainer, Stefan Beckert, Ruth Ladurner, Silvia Wagner, Florian Bullinger, Thorben H. Gross, Christopher Schroeder, Bence Sipos, Alfred Königsrainer, Stefan Stevanović, Carsten Denkert, Hans-Georg Rammensee, Cécile Gouttefangeas, Sebastian P. Haen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
radiofrequency ablation
liver metastasis
HLA ligandome
T cells
tumor-associated antigens
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02526/full

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