In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules
Computer aided drug-design methods proved to be powerful tools for the identification of new therapeutic agents. We employed a structure-based workflow to identify new inhibitors targeting mTOR kinase at rapamycin binding site. By combining molecular dynamics (MD) simulation and pharmacophore modell...
Main Authors: | Serena Vittorio, Rosaria Gitto, Ilenia Adornato, Emilio Russo, Laura De Luca |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/4/1103 |
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