The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus
IntroductionAutoimmune diseases result from the loss of immune tolerance, and they exhibit complex pathogenic mechanisms that remain challenging to effectively treat. It has been reported that the altered expression levels of co-stimulatory/inhibitory molecules will affect the level of T/B cell acti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1331796/full |
| _version_ | 1797336236449333248 |
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| author | Ding-Ping Chen Ding-Ping Chen Wei-Tzu Lin Fang-Ping Hsu Kuang-Hui Yu |
| author_facet | Ding-Ping Chen Ding-Ping Chen Wei-Tzu Lin Fang-Ping Hsu Kuang-Hui Yu |
| author_sort | Ding-Ping Chen |
| collection | DOAJ |
| description | IntroductionAutoimmune diseases result from the loss of immune tolerance, and they exhibit complex pathogenic mechanisms that remain challenging to effectively treat. It has been reported that the altered expression levels of co-stimulatory/inhibitory molecules will affect the level of T/B cell activation and lead to the loss of immune tolerance.MethodsIn this study, we evaluated the gene polymorphisms of the ligand genes corresponding co-stimulatory system that were expressed on antigen-presenting cells (CD80, CD86, ICOSLG, and PDL1) from 60 systemic lupus erythematosus (SLE) patients and 60 healthy controls.ResultsThe results showed that rs16829984 and rs57271503 of the CD80 gene and rs4143815 of the PDL1 gene were associated with SLE, in which the G-allele of rs16829984 (p=0.022), the A-allele of rs57271503 (p=0.029), and the GG and GC genotype of rs4143815 (p=0.039) may be risk polymorphisms for SLE.DiscussionThese SNPs are in the promoter and 3’UTR of the genes, so they may affect the transcription and translation activity of the genes, thereby regulating immune function and contributing to the development of SLE. |
| first_indexed | 2024-03-08T08:51:19Z |
| format | Article |
| id | doaj.art-7406338ef5f24a4197d827e90a1ef9df |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T08:51:19Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7406338ef5f24a4197d827e90a1ef9df2024-02-01T09:49:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011410.3389/fimmu.2023.13317961331796The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosusDing-Ping Chen0Ding-Ping Chen1Wei-Tzu Lin2Fang-Ping Hsu3Kuang-Hui Yu4Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanDivision of Rheumatology, Allergy, and Immunology, Linkou Chang Gung University and Memorial Hospital, Taoyuan, TaiwanIntroductionAutoimmune diseases result from the loss of immune tolerance, and they exhibit complex pathogenic mechanisms that remain challenging to effectively treat. It has been reported that the altered expression levels of co-stimulatory/inhibitory molecules will affect the level of T/B cell activation and lead to the loss of immune tolerance.MethodsIn this study, we evaluated the gene polymorphisms of the ligand genes corresponding co-stimulatory system that were expressed on antigen-presenting cells (CD80, CD86, ICOSLG, and PDL1) from 60 systemic lupus erythematosus (SLE) patients and 60 healthy controls.ResultsThe results showed that rs16829984 and rs57271503 of the CD80 gene and rs4143815 of the PDL1 gene were associated with SLE, in which the G-allele of rs16829984 (p=0.022), the A-allele of rs57271503 (p=0.029), and the GG and GC genotype of rs4143815 (p=0.039) may be risk polymorphisms for SLE.DiscussionThese SNPs are in the promoter and 3’UTR of the genes, so they may affect the transcription and translation activity of the genes, thereby regulating immune function and contributing to the development of SLE.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1331796/fullsystemic lupus erythematosuspromoter3 prime untranslated regioncostimulatory moleculesimmune regulatory genes |
| spellingShingle | Ding-Ping Chen Ding-Ping Chen Wei-Tzu Lin Fang-Ping Hsu Kuang-Hui Yu The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus Frontiers in Immunology systemic lupus erythematosus promoter 3 prime untranslated region costimulatory molecules immune regulatory genes |
| title | The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus |
| title_full | The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus |
| title_fullStr | The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus |
| title_full_unstemmed | The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus |
| title_short | The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus |
| title_sort | susceptibility of single nucleotide polymorphisms located within co stimulatory pathways to systemic lupus erythematosus |
| topic | systemic lupus erythematosus promoter 3 prime untranslated region costimulatory molecules immune regulatory genes |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1331796/full |
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