Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study
Objective: To assess whether exposure to non-invasive brain stimulation with transcranial alternating current stimulation at γ frequency (γ-tACS) applied over Pz (an area overlying the medial parietal cortex and the precuneus) can improve memory and modulate cholinergic transmission in mild cognitiv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Brain Stimulation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X21000589 |
| _version_ | 1818594446729543680 |
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| author | Alberto Benussi Valentina Cantoni Maria Sofia Cotelli Maria Cotelli Chiara Brattini Abhishek Datta Chris Thomas Emiliano Santarnecchi Alvaro Pascual-Leone Barbara Borroni |
| author_facet | Alberto Benussi Valentina Cantoni Maria Sofia Cotelli Maria Cotelli Chiara Brattini Abhishek Datta Chris Thomas Emiliano Santarnecchi Alvaro Pascual-Leone Barbara Borroni |
| author_sort | Alberto Benussi |
| collection | DOAJ |
| description | Objective: To assess whether exposure to non-invasive brain stimulation with transcranial alternating current stimulation at γ frequency (γ-tACS) applied over Pz (an area overlying the medial parietal cortex and the precuneus) can improve memory and modulate cholinergic transmission in mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Methods: In this randomized, double-blind, sham controlled, crossover pilot study, participants were assigned to a single 60 min treatment with exposure to γ-tACS over Pz or sham tACS. Each subject underwent a clinical evaluation including assessment of episodic memory pre- and post-γ-tACS or sham stimulation. Indirect measures of cholinergic transmission evaluated using transcranial magnetic stimulation (TMS) pre- and post-γ-tACS or sham tACS were evaluated. Results: Twenty MCI-AD participants completed the study. No tACS-related side effects were observed, and the intervention was well tolerated in all participants. We observed a significant improvement at the Rey auditory verbal learning (RAVL) test total recall (5.7 [95% CI, 4.0 to 7.4], p < 0.001) and long delayed recall scores (1.3 [95% CI, 0.4 to 2.1], p = 0.007) after γ-tACS but not after sham tACS. Face-name associations scores improved during γ−tACS (4.3 [95% CI, 2.8 to 5.8], p < 0.001) but not after sham tACS. Short latency afferent inhibition, an indirect measure of cholinergic transmission evaluated with TMS, increased only after γ-tACS (0.31 [95% CI, 0.24 to 0.38], p < 0.001) but not after sham tACS. Conclusions: exposure to γ-tACS over Pz showed a significant improvement of memory performances, along with restoration of intracortical connectivity measures of cholinergic neurotransmission, compared to sham tACS. |
| first_indexed | 2024-12-16T11:00:15Z |
| format | Article |
| id | doaj.art-74070403c413490893aea8e3d82b5814 |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-12-16T11:00:15Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-74070403c413490893aea8e3d82b58142022-12-21T22:34:01ZengElsevierBrain Stimulation1935-861X2021-05-01143531540Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot studyAlberto Benussi0Valentina Cantoni1Maria Sofia Cotelli2Maria Cotelli3Chiara Brattini4Abhishek Datta5Chris Thomas6Emiliano Santarnecchi7Alvaro Pascual-Leone8Barbara Borroni9Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili, Brescia, ItalyNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyNeurology Unit, Valle Camonica Hospital, Esine, Brescia, ItalyNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyNeurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili, Brescia, ItalyResearch & Development, Soterix Medical, Inc., New York, USAResearch & Development, Soterix Medical, Inc., New York, USABerenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USADepartment of Neurology, Harvard Medical School, Boston, MA, USA; Hinda and Arthur Marcus Institute for Aging Research and Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA; Guttmann Brain Health Institut, Institut Guttmann, Universitat Autonoma Barcelona, SpainNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili, Brescia, Italy; Corresponding author. Clinica Neurologica, Università degli Studi di Brescia P.le Spedali Civili 1, 25123, Brescia, Italy.Objective: To assess whether exposure to non-invasive brain stimulation with transcranial alternating current stimulation at γ frequency (γ-tACS) applied over Pz (an area overlying the medial parietal cortex and the precuneus) can improve memory and modulate cholinergic transmission in mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Methods: In this randomized, double-blind, sham controlled, crossover pilot study, participants were assigned to a single 60 min treatment with exposure to γ-tACS over Pz or sham tACS. Each subject underwent a clinical evaluation including assessment of episodic memory pre- and post-γ-tACS or sham stimulation. Indirect measures of cholinergic transmission evaluated using transcranial magnetic stimulation (TMS) pre- and post-γ-tACS or sham tACS were evaluated. Results: Twenty MCI-AD participants completed the study. No tACS-related side effects were observed, and the intervention was well tolerated in all participants. We observed a significant improvement at the Rey auditory verbal learning (RAVL) test total recall (5.7 [95% CI, 4.0 to 7.4], p < 0.001) and long delayed recall scores (1.3 [95% CI, 0.4 to 2.1], p = 0.007) after γ-tACS but not after sham tACS. Face-name associations scores improved during γ−tACS (4.3 [95% CI, 2.8 to 5.8], p < 0.001) but not after sham tACS. Short latency afferent inhibition, an indirect measure of cholinergic transmission evaluated with TMS, increased only after γ-tACS (0.31 [95% CI, 0.24 to 0.38], p < 0.001) but not after sham tACS. Conclusions: exposure to γ-tACS over Pz showed a significant improvement of memory performances, along with restoration of intracortical connectivity measures of cholinergic neurotransmission, compared to sham tACS.http://www.sciencedirect.com/science/article/pii/S1935861X21000589Transcranial alternate current stimulationMild cognitive impairmentAlzheimer diseaseTranscranial magnetic stimulation |
| spellingShingle | Alberto Benussi Valentina Cantoni Maria Sofia Cotelli Maria Cotelli Chiara Brattini Abhishek Datta Chris Thomas Emiliano Santarnecchi Alvaro Pascual-Leone Barbara Borroni Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study Brain Stimulation Transcranial alternate current stimulation Mild cognitive impairment Alzheimer disease Transcranial magnetic stimulation |
| title | Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study |
| title_full | Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study |
| title_fullStr | Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study |
| title_full_unstemmed | Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study |
| title_short | Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study |
| title_sort | exposure to gamma tacs in alzheimer s disease a randomized double blind sham controlled crossover pilot study |
| topic | Transcranial alternate current stimulation Mild cognitive impairment Alzheimer disease Transcranial magnetic stimulation |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X21000589 |
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